IL21, interleukin 21, 59067

N. diseases: 321; N. variants: 6
Disease: Ulcerative Colitis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.090 Biomarker disease BEFREE Our data indicate that TFH cells and IL-21 are involved in the pathogenesis of UC. 30855475 2019
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.090 Biomarker disease BEFREE According to the results, we hypothesize that the elevated level of IL-2+ and IL-21+ T cells and a positive correlation between IL-21+ cells with CAI in UC patients may contribute to the pathogenesis of disease. 28685527 2017
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.090 AlteredExpression disease BEFREE In both CD and UC, interleukin (IL)-12 (p40), IL-18, IL-21 and IL-27 transcript levels were higher than in Control. 28533995 2017
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.090 Biomarker disease BEFREE These observations indicate that IL-21 amplifies an inflammatory milieu that promotes CAC, and suggest that IL-21 blockade may be useful in reducing the risk of UC-associated colon cancer. 21987656 2011
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.090 GeneticVariation disease BEFREE The IL2/IL21 region may be one of the highly suggestive but so far rarely identified shared susceptibility loci for PSC and UC. 21304239 2011
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.090 GeneticVariation disease BEFREE In addition to the IL2/IL21 locus, we observed association of the TT genotype of SNP rs1545620 in MYO9B with UC (P = 0.0169; OR = 0.29, 95% CI 0.11-0.78) and association of rs17375018 in IL23R with pancolitis in Chinese UC patients (P = 0.002; OR = 2.38, 95% CI 1.41-4.02). 21648020 2011
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.090 GeneticVariation disease BEFREE Genotyping for UC-associated variants in the IL23R gene and in the IL2/IL21 region was performed. 20197757 2010
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.090 GeneticVariation disease BEFREE A strong association for the IL2/IL21 locus with UC was found, which also confirms it as a general susceptibility locus for inflammatory disease. 19201773 2009
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.090 GeneticVariation disease BEFREE Novel genetic risk markers for ulcerative colitis in the IL2/IL21 region are in epistasis with IL23R and suggest a common genetic background for ulcerative colitis and celiac disease. 19455118 2009