Lupus Erythematosus, Discoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
PD-1hiCXCR5- T peripheral helper cells promote B cell responses in lupus via MAF and IL-21.
|
31536480 |
2019 |
Lupus Erythematosus, Discoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Altogether, our results indicate that β2-Glycoprotein I is able to elicit a local Interleukin-17/Interleukin-21 and Interferon-γ inflammation in lupus-antiphospholipid syndrome patients that might lead, if unabated, to plaque instability and subsequent arterial thrombosis, suggesting that the T helper 17/T helper 1 pathway may represent a novel target for the prevention and treatment of the disease.
|
30872365 |
2019 |
Lupus Erythematosus, Discoid
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Enhanced ABC formation in SWEF-deficient mice was controlled by the cytokine IL-21 and IRF5, whose variants are strongly associated with lupus.
|
29483597 |
2018 |
Lupus Erythematosus, Discoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Anti-IL-21 treatment also led to a reduction in GC B cells, CD138<sup>hi</sup> plasmablasts, IFN-γ-dependent IgG2c production, and autoantibodies, indicating that Tfh cell-derived IL-21 is critical for pathological B cell cues in lupus.
|
28219887 |
2017 |
Lupus Erythematosus, Discoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
T cells contribute to lupus pathogenesis by secreting pro-inflammatory cytokines such as IL-17, and by interacting with B cells and secreting helper factors such as IL-21 that promote production of IgG autoantibodies.
|
24508410 |
2014 |
Lupus Erythematosus, Discoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Addition of IL-21 to lupus autologous mixed lymphocyte cultures induced significant IgG production, and treatment with IL-21R.Fc to block IL-21/IL-21R interaction reduced the proportion of plasma cells.
|
23137515 |
2013 |
Lupus Erythematosus, Discoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
We detected and confirmed gene-gene interactions between the HLA region and CTLA4, IRF5, and ITGAM and between PDCD1 and IL21 in patients with lupus.
|
21952918 |
2012 |
Lupus Erythematosus, Discoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our findings establish the genetic association between lupus and IL2/IL21 with a genome-wide level of significance.
|
21425124 |
2011 |
Lupus Erythematosus, Discoid
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The expression of IL-21 receptor (IL-21R) is reduced in the B cells of patients with systemic lupus erythematosus (SLE), while serum IL-21 levels are increased both in lupus patients and in some murine lupus models.
|
19644854 |
2009 |
Lupus Erythematosus, Discoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our data show for the first time that IL-21 has a pathogenic role in the MRL-Fas(lpr) lupus model by impacting B cell function and regulating the production of pathogenic autoantibodies.
|
17339481 |
2007 |
Lupus Erythematosus, Discoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
The mutation disrupts a repressor of ICOS, an essential co-stimulatory receptor for follicular T cells, and results in excessive production of the cytokine interleukin-21. sanroque mice fail to repress diabetes-causing T cells, and develop high titres of autoantibodies and a pattern of pathology consistent with lupus.
|
15917799 |
2005 |