IL21, interleukin 21, 59067

N. diseases: 321; N. variants: 6
Disease: Systemic Scleroderma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.050 Biomarker disease BEFREE The IL-21 pathway or JAK1/2 blockade by ruxolitinib could be a promising strategy in the treatment of SSc. 30760472 2019
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.050 Biomarker disease BEFREE Interleukin-21 neutralization in GVHD-SSc mice blocked disease pathogenesis by reducing skin fibrosis. 29514998 2018
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.050 AlteredExpression disease BEFREE Serum levels of IL-17 and IL-21 were increased in SSc patients compared with healthy controls and positively related to TL1A levels (r <sub>s</sub> = 0.373, P = 0.010; r <sub>s</sub> = 0.370, P = 0.011, respectively). 28397078 2017
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.050 AlteredExpression disease BEFREE The mRNA expression of IL-26, IL-22, IL-22R1, mRNA and protein expression of IL-17A, IL-21, IL-21R were positively correlated with the modified Rodnan skin score of SSc. 25500255 2015
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.050 GeneticVariation disease BEFREE These results suggested that the IL-2/IL-21 locus influences the genetic susceptibility to SSc. 23172754 2013