|
Rheumatoid Arthritis
|
0.300 |
Biomarker
|
disease |
CTD_human |
From transcriptome to proteome: differentially expressed proteins identified in synovial tissue of patients suffering from rheumatoid arthritis and osteoarthritis by an initial screen with a panel of 791 antibodies.
|
12833524 |
2003 |
|
Tumor Cell Invasion
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Here we demonstrate that the interaction of RAP2, a parasite-secreted rhoptry protein that functions in the parasitophorous vacuole formation stage of the invasion, and CD147 on the host erythrocyte is essential for erythrocyte invasion by <i>P falciparum</i> and is independent from all previously identified interactions involved.
|
29352039 |
2018 |
|
Tumor Cell Invasion
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
Our previous study indicated that the ectopic expression of Rap2a enhanced the migration and invasion ability of lung cancer cells.
|
28747626 |
2017 |
|
Tumor Cell Invasion
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
The results confirmed that Nedd4-1 inhibited GTP-Rap2a activity, and promoted the migration and invasion of glioma cells.
|
28405688 |
2017 |
|
Tumor Cell Invasion
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Overexpression of the dominant-active (DA-Rap2a), but not the dominant-negative (DN-Rap2a) form of Rap2a, also similarly inhibited the migration and invasion of glioma cells by reducing the phosphorylation level of AKT.
|
24293123 |
2014 |
|
Tumor Progression
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Ras-related protein (Rap)2a and Rap2b are members of the GTP-binding protein family, and serve an important function in tumor progression.
|
29552178 |
2018 |
|
Tumor Progression
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Expression of ARV-PBS target genes, such as oncogene RAP2A and cell cycle gene E2F7, were significantly associated with castration resistance, poor survival and tumor progression.
|
29309643 |
2018 |
|
Tumor Progression
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Rap2a, a member of the small GTPase superfamily, belongs to Ras superfamily, and its function in cancer progression is still poorly understood.
|
28747626 |
2017 |
|
Glioma
|
0.020 |
Biomarker
|
disease |
BEFREE |
In brief, our findings demonstrated the important role of Nedd4-1 in regulating the migration and invasion of glioma cells via the Nedd4-1/Rap2a pathway, which may qualify Nedd4-1 as a viable therapeutic target for glioma.
|
28405688 |
2017 |
|
Glioma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In contrast, downregulation of Rap2a promoted glioma migration and invasion, and raised the phosphorylation level of AKT, whereas these effects were inhibited by PI3K-specific inhibitor, LY294002.
|
24293123 |
2014 |
|
Muscle Rigidity
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Here we identified the Ras-related GTPase RAP2 as a key intracellular signal transducer that relays ECM rigidity signals to control mechanosensitive cellular activities through YAP and TAZ.
|
30135582 |
2018 |
|
Parasitemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Moreover, mice infected with RAP2/3-deficient parasites showed low levels of parasitemia and ultimately recovered from the infection The aim of this study was to investigate the effect of RAP2/3 expression on the outcome of infection with Pb XAT using a RAP2/3-expressing Pb XAT.
|
29307564 |
2018 |
|
Renal Cell Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Rap2a had no effect on the proliferation of RCC cell lines.
|
28747626 |
2017 |
|
Neoplasm Metastasis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
In vivo studies also showed that Rap2a positively regulated metastasis of renal cancer cells and the expression of p-Akt.
|
28747626 |
2017 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Rap2a had no effect on the proliferation of RCC cell lines.
|
28747626 |
2017 |
|
Peripheral Arterial Diseases
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Fine-mapping at the IPO5/RAP2A locus revealed that rs9584669 conferred risk of PAD.
|
26488411 |
2015 |
|
Malignant neoplasm of prostate
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Twelve genes (BAG1, DDR1, ERBB4, ESR1, HSPD1, IGFBP2, IGFBP5, NR4A1, PAWR, PIK3CG, RAP2A, and TPD52) were found to be associated with both HNF1b and prostate cancer risk.
|
23661456 |
2013 |
|
Prostate carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Twelve genes (BAG1, DDR1, ERBB4, ESR1, HSPD1, IGFBP2, IGFBP5, NR4A1, PAWR, PIK3CG, RAP2A, and TPD52) were found to be associated with both HNF1b and prostate cancer risk.
|
23661456 |
2013 |
|
Cerebral Cavernous Malformations 3
|
0.010 |
Biomarker
|
disease |
BEFREE |
CCMs can occur sporadically or as a familial autosomal dominant condition with incomplete penetrance and variable clinical expression attributable to mutations in three different genes: CCM1 (K-Rev interaction trapped 1 (KRIT1)), CCM2 (MGC4607), and CCM3 (PDCD10).
|
24058906 |
2013 |
|
Thyroid Neoplasm
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
To identify targets of RAP1GAP downregulation in the thyroid gland, RAP1 and RAP2 protein expression in human thyroid cells and in primary thyroid tumors were analyzed.
|
22696507 |
2012 |
|
Anaplastic thyroid carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
To explore the functional significance of RAP1GAP depletion, RAP1GAP was transiently expressed at the lowest level that is sufficient to block endogenous RAP2 activity in papillary and anaplastic thyroid carcinoma cell lines.
|
22696507 |
2012 |
|
Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Importantly, treatment with HDAC inhibitors impaired Rap2 activity in both differentiated and anaplastic tumor cell lines.
|
21367844 |
2011 |
|
Prostatic Neoplasms
|
0.010 |
AlteredExpression
|
group |
LHGDN |
Rap2 regulates androgen sensitivity in human prostate cancer cells.
|
17918750 |
2007 |
|
Malignant neoplasm of breast
|
0.010 |
Biomarker
|
disease |
BEFREE |
Rap2 belongs to the Ras superfamily of GTPases, whose role in breast cancer remains unknown.
|
15986426 |
2005 |
|
Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Rap2 belongs to the Ras superfamily of GTPases, whose role in breast cancer remains unknown.
|
15986426 |
2005 |