|
granulosa cell tumor
|
0.310 |
Biomarker
|
disease |
CTD_human |
At low nanomolar concentrations, BPA, TBBPA, and TCBPA decreased chemerin expression and secretion only in granulosa cell tumor COV434 cells by both peroxisome proliferator-activated receptor γ and estrogen receptor signaling pathways.
|
29653259 |
2018 |
|
granulosa cell tumor
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
At low nanomolar concentrations, BPA, TBBPA, and TCBPA decreased chemerin expression and secretion only in granulosa cell tumor COV434 cells by both peroxisome proliferator-activated receptor γ and estrogen receptor signaling pathways.
|
29653259 |
2018 |
|
Impaired glucose tolerance
|
0.310 |
Biomarker
|
phenotype |
CTD_human |
Chemerin regulates β-cell function in mice.
|
22355640 |
2011 |
|
Impaired glucose tolerance
|
0.310 |
Biomarker
|
phenotype |
BEFREE |
Chemerin was reported to modulate insulin sensitivity in adipocytes and skeletal muscle cells in vitro and to exacerbate glucose intolerance in several mouse models in vivo.
|
20724582 |
2010 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.300 |
Biomarker
|
disease |
BEFREE |
The purpose of this study was to identify the relationship of chemerin and TNF-α with mitochondrial DNA (mtDNA) copy number in subcutaneous adipose tissue (SAT) and visceral adipose tissue (mesentery of the small intestine (Mes), greater omentum (GO) and blood mononuclear cells (MNCs)) in patients with obesity with/without type 2 diabetes mellitus (T2DM).
|
30871547 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.300 |
Biomarker
|
disease |
BEFREE |
Collectively, chemerin, factors associated with obesity, pathological and physiological changes in glucolipid metabolism, and inflammatory factors may promote the development of T2DM macroangiopathy.
|
31078135 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The aim of this study was to explore the correlation between plasma chemerin levels and microangiopathy in patients with T2DM.
|
31379940 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.300 |
Biomarker
|
disease |
RGD |
Aerobic exercise decreases chemerin/CMKLR1 in the serum and peripheral metabolic organs of obesity and diabetes rats by increasing PPARγ.
|
30873215 |
2019 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Adipokine chemerin was known for its relationship with obesity as well as metabolism.
|
31781638 |
2019 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
In humans, chemerin is positively associated with blood pressure and obesity so we hypothesized that in a model of hypertension derived from high-fat (HF) feeding, the chemerin ASO would reduce blood pressure more than a high-salt (HS) model.
|
31588871 |
2019 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Collectively, chemerin, factors associated with obesity, pathological and physiological changes in glucolipid metabolism, and inflammatory factors may promote the development of T2DM macroangiopathy.
|
31078135 |
2019 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
RGD |
To evaluate the effects of probiotic supplementation on chemerin level, inflammation, and metabolic syndrome components in obese Wistar rats.
|
31284705 |
2019 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Chemerin Isoforms and Activity in Obesity.
|
30841637 |
2019 |
|
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In the CAD population, borderline significance was noted between <i>RARRES2</i> polymorphisms and chemerin levels, whereas high chemerin levels were associated with obesity, female sex, diabetes mellitus, hypertension, current smoking, high platelet and leukocyte counts, anemia, impaired renal function, high C-reactive protein (CRP) levels, and multi-vessel disease.
|
30866520 |
2019 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
RGD |
Besides serum chemerin, the levels of chemerin/CMKLR1 in the metabolic organs of obesity and diabetes rats were alleviated by exercise, which were likely to be associated with the improvement of glycolipid metabolism.
|
30873215 |
2019 |
|
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
To investigate the influences of exercise on the levels of chemerin and its receptor chemokine-like receptor (CMKLR1) in the peripheral metabolic organs of obesity and diabetes rats, and whether the mechanism is related to peroxisome proliferator activated receptor γ (PPARγ), a key modulator of glycolipid metabolism.
|
30873215 |
2019 |
|
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In this study, we evaluated the expression and function of chemerin and CMKLR1 in the ovaries and granulosa cells of high-fat diet-induced obese (OB) mice.
|
30722991 |
2019 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Additional studies are required to determine if obesity influences cancer initiation or progression through increased adipose tissue production of chemerin and/or altered chemerin processing that leads to changes in chemerin signaling in the tumor microenvironment.
|
31561459 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.300 |
Biomarker
|
disease |
BEFREE |
The aim of the study was to investigate the effects of blood glucose, serum chemerin and insulin resistance on non-alcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus to provide a basis for the prevention and treatment thereof.
|
29456698 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.300 |
Biomarker
|
disease |
BEFREE |
We aimed to determine whether chemerin reduces vascular insulin signaling and whether there is interplay between chemerin/ChemR23, insulin resistance, and vascular complications associated with type 2 diabetes (T2D).
|
30216119 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Chemerin, a chemoattractant protein, acts <i>via</i> a G-protein coupled chemokine receptor, <i>i.e.</i> Chemokine like Receptor 1/ChemR23; levels of which are elevated in pro-inflammatory states such as obesity and type 2 diabetes mellitus (T2DM).
|
29682177 |
2018 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
While increased total serum chemerin is a consistent finding among rodent obesity models, this may not accurately reflect changes in chemerin bioactivity which is the major determinant of biological effects.
|
29414326 |
2018 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Given the association of chemerin with obesity and related diseases, we decided to study in detail the regulation of chemerin and CMKLR1 expression in white adipose tissue (WAT).
|
30257454 |
2018 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Furthermore, proteomic analysis of the adipose tissue secretome has recently identified several novel adipokines including vaspin, chemerin and pref-1 that are associated with obesity and insulin resistance in humans and functionally impact on insulin signalling pathways.
|
29760587 |
2018 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
<b>Conclusions:</b> PEDF and Chemerin arose as biomarkers of obesity and metaflammation respectively, providing a link between chronic inflammation and excess of body weight in RA.
|
30123797 |
2018 |