Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
We aimed to synthesize epigenomic findings in HTN namely (a) angiotensin-converting enzyme 2 (ACE II) gene, (b) Toll-like receptor 2 (TLR2) gene, (c) interferon γ (IFN-γ) gene, and (d) Capping Actin Protein, Gelosin-Like (<i>CAPG</i>) <i>gene</i>, adducin 1(ADD1) gene, (e) Tissue inhibitor of metalloproteinase 3 (<i>TIMP3</i>), (f) mesoderm specific transcript (MEST) loci, (g) sodium channel epithelial 1 alpha subunit 2 (SCNN1B), (h) glucokinase (CKG) gene (i) angiotensin II receptor, type1 (AGTR1), and DNA methylation (mDNA).
|
31805646 |
2019 |
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Therefore it is of no surprise that animals with genetic alterations in the expression of ACE2 develop a diverse pattern of phenotypes ranging from hypertension, metabolic and behavioural dysfunctions, to impairments in serotonin synthesis and neurogenesis.
|
30443713 |
2019 |
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Chronically, SAT mice exhibited a blunted blood pressure elevation and preserved ACE2 activity during development of salt-sensitive hypertension.
|
31564162 |
2019 |
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Here, we studied the mRNA and protein expression of cardiac angiotensin-converting enzyme 2 (ACE2) in the chronic phase of a rat model of 2-kidney, 1-clip hypertension (2K1C), and the effects of 2-week alamandine infusion on blood pressure, cardiac indices, and ACE2 mRNA and protein expression in the hearts.
|
30956259 |
2019 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Hypertension and hypertensive left ventricular hypertrophy are associated with ACE2 genetic polymorphism.
|
30917908 |
2019 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Association of ACE2 genetic polymorphisms with hypertension-related target organ damages in south Xinjiang.
|
30542083 |
2019 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Angiotensin-converting enzyme 2 (ACE2) in the brain plays beneficial roles in cardiovascular function in hypertension.
|
30318562 |
2019 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Although these preliminary findings must be confirmed by further researches with larger sample size, we could observe that the integrative analysis of ACE and ACE2 can be an informative tool in hypertension understanding that needs to be explored in new studies.
|
31430320 |
2019 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
In this work, we hypothesized that RGZ exerts a PPAR<i>γ</i>-dependent regulation of blood pressure through modulation of angiotensin-converting enzyme (ACE)-type 2 (ACE2)/angiotensin-(1-7)/angiotensin II type-2 receptor (AT<sub>2</sub>R) axis in an experimental model of high blood pressure.
|
30863432 |
2019 |
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
The results indicated that taurine regulated the hypothalamus pituitary adrenal (HPA) axis of the renin-angiotensin-aldosterone system (RAAS) by inhibiting ACE gene and protein expressions and promoting ACE2 and HSP70 protein expressions, thereby contributing to the prevention of stress-induced hypertension.
|
28849507 |
2018 |
Hypertensive disease
|
0.600 |
PosttranslationalModification
|
group |
BEFREE |
AMP-activated Protein Kinase Phosphorylation of Angiotensin-Converting Enzyme 2 in Endothelium Mitigates Pulmonary Hypertension.
|
29570986 |
2018 |
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Thus, FGF21 protects against angiotensin II-induced hypertension and vascular impairment by activation of the ACE2/angiotensin-(1-7) axis via fine-tuning the multi-organ crosstalk between liver, adipose tissue, kidney, and blood vessels.
|
29706566 |
2018 |
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Emerging evidence also suggests that, in part, the female protective phenotype against hypertension may be due to inceased ACE2 activity within cardiovascular regulatory regions of the brain, potentially mediated by estrogen.
|
29480460 |
2018 |
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Previous studies showed that injection of the enzymatic ectodomain of recombinant ACE2 (rACE2) markedly increases circulatory levels of ACE2 activity, and effectively lowered blood pressure in angiotensin II-induced hypertension.
|
29691064 |
2018 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
We find no influence of ACE2 gene polymorphism on stroke recurrence and only find possible interaction between hypertension history and the ACE2 gene in male stroke patients.
|
30056001 |
2018 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Elevated plasma ACE2 was associated with older age, male gender, hypertension and vascular disease, elevated left ventricular (LV) mass, impaired LV diastolic function and advanced atrial disease (P < 0.05 for all).
|
27738071 |
2017 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
The present review examined recent findings regarding the physiological and biological roles of the ACE2‑Ang‑(1‑7)‑Mas axis in the cardiovascular system, discussed potential food‑derived ACE2‑activating agents, and highlighted initiatives, based on this axis, that aim to develop functional foods for the treatment of hypertension.
|
28791402 |
2017 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
These results suggest that insufficiency of hypothalamic ACE2 is associated with hypertension in SHR rats.
|
28423630 |
2017 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
However, the newly discovered angiotensin-converting enzyme 2 (ACE2)/angiotensin-(1-7)/Mas receptor axis added new vitality to the hypertension field.
|
28500596 |
2017 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Large body of experimental data confirmed sustained beneficial effects of ACE2/Ang-(1-7)/Mas receptor axis activation on hypertension and vascular injury.
|
27889958 |
2017 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
ACE2 is important in understanding the balance between AngII and Ang-(1-7) and how this balance could then in turn influence hypertension or other disease outcomes.
|
28500595 |
2017 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
In order to assess the role of brain ACE2 in hypertension, a specific ACE2 assay is required.
|
28116711 |
2017 |
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
We previously reported that it is also associated with a reduction of angiotensin-converting enzyme type 2 (ACE2) and an increase in a disintegrin and metalloprotease 17 (ADAM17) activity in experimental hypertension.
|
28512108 |
2017 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The study identified ACE II genotype (odds ratio = 3.02; 95% CI 1.40-6.51), smoking, hypertension, diabetes and serum triglyceride > 150 mg/dl as independent risk factors for MI.
|
26687160 |
2016 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The circulating ACE2 and Ang-(1-7) levels were related to neither rs4646155 nor rs879922 in female or male patients.In conclusion, the rs2106809 polymorphism of the ACE2 gene may be a determinant of the circulating Ang-(1-7) level in female patients with hypertension, suggesting a genetic association between circulating Ang-(1-7) levels and ACE2 gene polymorphisms in patients with hypertension.
|
27310975 |
2016 |