SENP2, SUMO specific peptidase 2, 59343

N. diseases: 49; N. variants: 6
Disease: Malignant Neoplasms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.020 Biomarker group BEFREE Small ubiquitin related modifier (SUMO)‑specific protease 2 (SENP2) can act as a suppressor in various types of cancer by regulating the stability of β‑catenin to affect the Notch signaling pathway; however, it has a low expression level in CLL cells. 30431078 2019
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.020 Biomarker group BEFREE Altogether, our data show how SENP2 regulates its substrate for desumoylation, and also the role of SENP2 in TGF-β induced cancer cell migration. 29955155 2018