|
Lip and Oral Cavity Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In total, 28 loci, that is, 14q32.33 (AKT1), 5q22.2 (APC), 11q22.3 (ATM), 2q33.1 (CASP8), 11q13.3 (CCND1), 16q22.1 (CDH1), 9p21.3 (CDKN2A), 1q31.1 (COX-2), 7p11.2 (EGFR), 22q13.2 (EP300), 4q35.2 (FAT1), 4q31.3 (FBXW7), 4p16.3 (FGFR3), 1p13.3 (GSTM1-GSTT1), 11q13.2 (GSTP1), 11p15.5 (H-RAS), 3p25.3 (hOGG1), 1q32.1 (IL-10), 4q13.3 (IL-8), 12p12.1 (KRAS), 12q15 (MDM2), 12q13.12 (MLL2), 9q34.3 (NOTCH1), 17p13.1 (p53), 3q26.32 (PIK3CA), 10q23.31 (PTEN), 13q14.2 (RB1), and 5q14.2 (XRCC4), were validated to be associated with oral cancer.
|
29037125 |
2017 |
|
Lip and Oral Cavity Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
CCND1 gene and its protein cyclin D1 are frequently altered by different molecular mechanisms, including amplification, chromosomal translocations, mutations, and activation of the pathways involved in cyclin D1 expression, alterations which appear to be essential in the development of human cancers, including oral carcinoma.
|
27973759 |
2017 |
|
Lip and Oral Cavity Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Chromosomal region 11q13, including genes CCND1, Fas-associated death domain (FADD), and CTTN, is often amplified in oral cancer with nodal metastases.
|
27653309 |
2017 |
|
Lip and Oral Cavity Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The study aims to evaluate the expression and activity of glycogen synthase kinase 3 isoforms α/β (GSK3α/β) and to assess their oncogenic potential through a correlation with the expression of cyclin D1 and p53 in oral cancer.
|
25645517 |
2015 |
|
Lip and Oral Cavity Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A significant risk of oral cancer was also evident for individual polymorphisms of cyclin E (rs1406), cyclin H (rs3093816), cyclin D1-1 (rs647451), cyclin D2 (rs3217901) and Rb1-2 (rs3092904).
|
24947332 |
2014 |
|
Lip and Oral Cavity Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Taken together, the meta-analysis revealed that CCND1 G870A polymorphism might be correlated with the susceptibility of oral cancer in Asians.
|
24186074 |
2014 |
|
Lip and Oral Cavity Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that CCND1 G870A has no, or only very limited, predictive and prognostic value for oral carcinoma.
|
24403468 |
2014 |
|
Lip and Oral Cavity Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We used the odds ratio (OR) and hazard ratio (HR) as the common measures of association to quantitatively determine the correlation between cyclin D1 overexpression and outcomes of oral cancer.
|
24675814 |
2014 |
|
Lip and Oral Cavity Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In the subgroup analysis, the CCND1 G allele was associated with a borderline significantly decreased risk of developing oral cancer in Asians in the frequency of allele comparison (G vs. A: OR = 0.800; 95 % CI = 0.636-1.006; p = 0.089 for heterogeneity), and the association between the GG genotype and oral cancer was significant in Asians with respect to both the homozygote comparison (GG vs. AA: OR = 0.644; 95 % CI = 0.491-0.843; p = 0.186 for heterogeneity) and the dominant genetic model (GG + AG vs. AA: OR = 0.713; 95 % CI = 0.584-0.870; p = 0.293 for heterogeneity).
|
23111452 |
2013 |
|
Lip and Oral Cavity Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We hypothesized that polymorphisms in CCND1 +870A>G and VEGF +936C>T genes are not correlated with the development of oral cancer.
|
22321253 |
2012 |
|
Lip and Oral Cavity Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
There was an obvious joint effect of CCND1 rs9344 genotype with smoking habit on oral cancer.
|
21273603 |
2011 |
|
Lip and Oral Cavity Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our clinical data provide the first evidence that there is a strong inverse correlation between DEC1 and cyclin D1 expression in oral cancer, and DEC1 expression significantly correlated with clinicopathological parameters.
|
21506129 |
2011 |
|
Lip and Oral Cavity Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Higher expression of cyclin D1 in oral cancer appears to be closely linked to cell proliferation, differentiation and lymph node invasion.
|
21537090 |
2011 |
|
Lip and Oral Cavity Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We also studied the expression of EGFR, beta-catenin, and cyclin D1 in 112 samples of oral cancer by immunostaining.
|
20302655 |
2010 |
|
Lip and Oral Cavity Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cyclin D1 protein accumulation has been observed in 31.3% (16/51) of the OSCC samples whereas the normal oral mucosa and the PML showed no immunoreactivity.
|
19679297 |
2009 |
|
Lip and Oral Cavity Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Detection of copy number amplification of cyclin D1 (CCND1) and cortactin (CTTN) in oral carcinoma and oral brushed samples from areca chewers.
|
19666237 |
2009 |
|
Lip and Oral Cavity Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Recently, we have reported overexpression of cyclin D1 in oral carcinoma.
|
18061526 |
2008 |
|
Lip and Oral Cavity Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The detection of CCND1 and p16 aberrations using a simple and sensitive method would be valuable for the development of effective treatment modalities for oral cancer.
|
17893905 |
2007 |
|
Lip and Oral Cavity Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The comparison of the CCND1 A870G and C1722G genotype frequencies in cases and controls did not show any significant association with oral cancer risk.
|
16488657 |
2006 |
|
Lip and Oral Cavity Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Here, the transcription and translational upregulation of cyclin D1 was observed in most of the tobacco chewing oral cancer patients where as the gene amplification was limited to only small group (20%) of patients.
|
16172916 |
2005 |
|
Lip and Oral Cavity Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Abnormal beta-catenin expression in oral cancer with no gene mutation: correlation with expression of cyclin D1 and epidermal growth factor receptor, Ki-67 labeling index, and clinicopathological features.
|
15791567 |
2005 |
|
Lip and Oral Cavity Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Role of p16/MTS1, cyclin D1 and RB in primary oral cancer and oral cancer cell lines.
|
10389982 |
1999 |