|
Cervix carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A total of 60 biopsy samples (40 normal and 20 ADCs of CC) were analyzed for the expression of Cyclin D1 in HPV associated ADCs via immunohistochemistry and by immunoblotting.
|
30903019 |
2019 |
|
Cervix carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression Of Cyclin D1 Protein Isoforms And Its Prognostic Significance In Cervical Cancer.
|
31695498 |
2019 |
|
Cervix carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In general, this article disclosed that NEAT1 could facilitate the radio-resistance of cervical cancer via competitively binding miR-193b-3p to up-regulate the expression of cyclin D1.
|
29416780 |
2018 |
|
Cervix carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The CC cells were transfected with siRNA or si-NC against ANRIL to find out whether ANRIL can influence the expression of Cyclin D1, CDK4, CDK6, E-cadherin, vimentin and N-cadherin, as well as affect cell proliferation, cell apoptosis, cell migration and cell invasion of CC cells.
|
30198868 |
2018 |
|
Cervix carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
However, in case of cervical cancer risk a non-significant association was reported under the recessive model (GG+GA vs AA: OR = 1.52, 95%CI = 0.60-3.90, <i>P</i>=0.38) with reference to <i>CCND1</i> polymorphism (rs9344).
|
30361291 |
2018 |
|
Cervix carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
OVCA1 expression and its correlation with the expression levels of cyclin D1 and p16 in cervical cancer and intraepithelial neoplasia.
|
28521400 |
2017 |
|
Cervix carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We further investigated the molecular mechanisms of miR-195 and cyclin D1 in CC cell lines HeLa and SiHa.
|
26631043 |
2016 |
|
Cervix carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In this work, we found that the expression of miR-202 is obviously decreased in both CC cell lines and tissues, and negatively related with the expression of cyclin D1 in SiHa, HeLa and Caski cells.
|
27732565 |
2016 |
|
Cervix carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, we identified a new pathway employing miR-2861, EGFR, AKT2, and CCND1 that may mediate HPV16 E6 induced initiation and progression of cervical cancer.
|
27364926 |
2016 |
|
Cervix carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our meta-analysis indicated that CCND1 G870A might be not the crucial risk factor for the development of cervical cancer.
|
25204741 |
2014 |
|
Cervix carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In summary, the present meta-analysis provides evidence that genotypes for the cyclin D1 (CCND1) G870A polymorphism may be not associated with genetic susceptibility of cervical cancer.
|
24737585 |
2014 |
|
Cervix carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The present results show that PAI-1 overexpression is associated with nonhomologous end-joining DNA repair down-regulation (low Ku70/80 expression) and with increased p53 and cyclin D1 expression, and they suggest that PAI-1 plays a role in the tumor behavior in cervical carcinoma.
|
23111469 |
2012 |
|
Cervix carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
CCND1 rs9344 polymorphisms are associated with the genetic susceptibility to cervical cancer in Chinese population.
|
21594903 |
2012 |
|
Cervix carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Distribution of CCND1 A870G polymorphism in patients with advanced uterine cervical carcinoma.
|
20680537 |
2011 |
|
Cervix carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The G870A polymorphism in CCND1 may not contribute to the etiology of cervical cancer in Chinese populations.
|
20473525 |
2011 |
|
Cervix carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A significant association of CxCa with various polymorphisms was observed: rs1800797 in the IL-6 gene (odds ratio [OR] = 0.88, 95% confidence intervals [CI]: 0.79-0.99); rs1041981 in the LTA gene (OR = 0.87, 95% CI: 0.78-0.98), and rs9344 in the CCND1 gene (OR = 1.14, 95% CI: 1.02-1.27), for those individuals carrying the rare allele.
|
19585495 |
2009 |
|
Cervix carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our data suggest that CCND1 G870A polymorphism could act as a risk factor for the development of cervical cancer.
|
19489683 |
2009 |
|
Cervix carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
No significant association was observed between CCND1 genotypes and overall risk of cervix cancer.
|
18548202 |
2008 |
|
Cervix carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
It is suggested that Pin1 may contribute to cervical tumorigenesis by regulating cyclin D1 expression and Pin1 may serve as a promising molecular target for diagnostics and therapeutics in cervical cancer.
|
16865248 |
2006 |
|
Cervix carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Thus, we undertook this study to investigate the association between CCND1 polymorphisms and susceptibility to cervical cancer in Korean women.
|
15896460 |
2005 |
|
Cervix carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The proportion of cervical cancer cases attributable to the GG CCND1 genotype was 17.26%.
|
15949570 |
2005 |
|
Cervix carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Many of the heterogeneous regions contained genes known to influence the prognosis of cervical cancer, such as 7p (EGFR), 8q (c-MYC), 11qcen-q13 (CCND1) and 17q (ERBB2).
|
15221962 |
2004 |
|
Cervix carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Underexpression of cyclin D1 was regulated at the level of transcription in cervical cancer.
|
11371120 |
2001 |
|
Cervix carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Disease stage, tumor grade and overexpression of cyclin D1 were found to be independent poor prognostic factors in cervical carcinoma.
|
11311493 |
2001 |