Endometrial Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Ki-67 and CCND1 expressions in tumors of xenograft mice were analyzed with immunohistochemical assay. miR-142 was expressed at a lower level in human EC tumor samples than matched normal tissues, and its mRNA level in EC patients without metastasis was higher than that in patients with metastatic EC.
|
30585737 |
2019 |
Endometrial Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Importantly, our data showed that engineered extracellular vesicles rich in miR-302 significantly inhibited the expression of cyclin D1 and suppressed AKT signaling pathway in endometrial cancer cells.
|
31001342 |
2019 |
Endometrial Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We demonstrated that NR1H3 is upregulated in endometrial adenocarcinoma and that it inhibits cell viability by inhibiting the expression of CCND1 and CCNE in endometrial carcinoma cells.
|
30705597 |
2019 |
Endometrial Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Further investigation revealed that the synergistic inhibitory effect of the two agents on EC can be at least partly, explained by the decreased expression of cyclin D1 and cyclin E. The results of the current study provide novel insights into the treatment of EC.
|
29393479 |
2018 |
Endometrial Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Cyclin D1 is significantly associated with stage of tumor and predicts poor survival in endometrial carcinoma patients.
|
28965628 |
2017 |
Endometrial Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We report a subset of cancers highly sensitive to CDK4/6 inhibition and characterized by various genomic aberrations known to elevate D-cyclin levels and describe a recurrent CCND1 3'UTR mutation associated with increased expression in endometrial cancer.
|
29232554 |
2017 |
Endometrial Carcinoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
We report a subset of cancers highly sensitive to CDK4/6 inhibition and characterized by various genomic aberrations known to elevate D-cyclin levels and describe a recurrent CCND1 3'UTR mutation associated with increased expression in endometrial cancer.
|
29232554 |
2017 |
Endometrial Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The number of cells displaying membranous or cytoplasmic Ccnd1 was significantly higher in peripheral cells than in inner cells in both collective and pushing invasion patterns of endometrial carcinoma, and in collective invasion pattern of colon carcinoma.
|
27105504 |
2016 |
Endometrial Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Cyclin D1 harboring the T286I mutation promotes oncogenic activation in endometrial cancer.
|
23733133 |
2013 |
Endometrial Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Serum levels of insulin, p-p52Shc, p-p46Shc, Shc·Grb2 complexes, p-MEK, p-ERK, and cyclin D1 were elevated in patients with EC.
|
22459351 |
2012 |
Endometrial Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that the cyclin D1 870 G>A polymorphism is possibly involved in the development of endometrial cancer.
|
18822177 |
2008 |
Endometrial Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We assessed the association between the CCND1 G870A polymorphism and the risk of endometrial cancer in a hospital-based case-control study among 231 Korean women (77 cases; 154 matched controls).
|
15863141 |
2005 |
Endometrial Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Disruptions at p16INK4A and/or cdk4/cyclin D1 concomitantly occurring with TP53 LOH may participate in the development of a subset of endometrioid-type ECs.
|
16293976 |
2005 |
Endometrial Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
As a conclusion, derailments of the Rb-pathway components, cyclin D1 and cdk4 in particular, seems to participate in the endometrial cancer development in humans.
|
14648178 |
2004 |
Endometrial Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Molecular alterations associated with cyclin D1 overexpression in endometrial cancer.
|
15069681 |
2004 |
Endometrial Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
To test whether similar genetic changes may occur in vivo, we analysed a series of 60 endometrioid endometrial carcinomas (EECs) for cyclin D1 expression and gene amplification by immunohistochemistry and FISH, respectively.
|
12955092 |
2003 |
Endometrial Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The results also suggest that MMP-7 and particularly cD may be targets of beta-catenin activation in ECs.
|
11957146 |
2002 |
Endometrial Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Three genes (Decorin, TIMP3 and Cyclin D1) were identified to be differentially expressed between the benign endometrial tissue sample and the endometrial carcinoma samples (tissue and cell-lines).
|
10901378 |
2000 |
Endometrial Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The expression of cyclin D1 was restricted to only a few cells of normal and hyperplastic endometrium, whereas it was preferentially expressed in 40% (30/74) of endometrial carcinomas.
|
8826947 |
1996 |