|
Centrocytic lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The sequence of the overexpressed PRAD1 genes has been directly analyzed in only two tumor specimens, a benign parathyroid adenoma and a malignant centrocytic lymphoma.
|
7621424 |
1995 |
|
Centrocytic lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Approximately 70% of centrocytic (mantle-cell) lymphomas have the chromosomal translocation t(11;14) (q13; q32) and associated rearrangements at the bcl-1 breakpoint locus and at the cyclin D1 (PRAD1, CCND1) gene, thus implicating this gene in the pathogenesis of centrocytic lymphoma.
|
8172823 |
1994 |
|
Centrocytic lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The coincidence of anaplastic and sometimes blast-like morphology of the tumour cells, high proliferation index and a rearranged bcl-1 gene in nearly all cases of anaplastic centrocytic lymphoma support their classification as high-grade malignant variants of centrocytic lymphoma and suggest a possible role for the bcl-1 locus not only in the origin but also in the progression of centrocytic lymphomas.
|
8045522 |
1994 |
|
Centrocytic lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We have sequenced the coding region of the overexpressed PRAD1 transcript from two primary tumors with clonal PRAD1 region rearrangements: a benign parathyroid adenoma and a malignant centrocytic lymphoma.
|
8426754 |
1993 |
|
Centrocytic lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We used various probes covering a considerable proportion of the 120-kilobase BCL-1 locus, and rearrangements in 50% of CC/IDL (10 of 20) were detected.
|
8364907 |
1993 |
|
Centrocytic lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Chromosome t(11;14)(q13;q32) breakpoints in centrocytic lymphoma are highly localized at the bcl-1 major translocation cluster.
|
8371593 |
1993 |
|
Centrocytic lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Probes are currently available to study the c-myc translocations of Burkitt's lymphoma, the bcl-2 translocations of follicular lymphomas, and the bcl-1 translocations of centrocytic lymphoma.
|
8476269 |
1993 |
|
Centrocytic lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, translocation-induced aberrant expression of the PRAD1 cyclin may lead to deregulated cell cycle control and play an important role in the pathogenesis of centrocytic lymphoma.
|
8426477 |
1993 |
|
Centrocytic lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
However, in centrocytic lymphoma rearrangement of the BCL-1 oncogene has been detected in up to 50% of cases.
|
1520625 |
1992 |
|
Centrocytic lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, bcl-1 and PRAD1 rearrangement is strongly associated with centrocytic lymphoma, providing a useful molecular marker for classifying this subtype of lymphoma and suggesting an important role for PRAD1 cyclin D1 in the pathogenesis of this neoplasm.
|
1394169 |
1992 |
|
Centrocytic lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Its overexpression may be a key consequence of rearrangement of the BCL1 vicinity in B-cell neoplasms and a unifying pathogenetic feature in centrocytic lymphoma.
|
1682919 |
1991 |
|
Centrocytic lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
To further characterize the association between bcl-1 and centrocytic lymphoma, Southern blot analysis was performed on samples from 23 patients using four separate bcl-1 breakpoint probes spanning 63 kb of the chromosome 11 bcl-1 locus.
|
2070085 |
1991 |
|
Centrocytic lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This incidence of bcl-1 rearrangement in centrocytic lymphoma suggests that it is a characteristic change.
|
2250191 |
1990 |
|
Centrocytic lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Genotypic characterization of centrocytic lymphoma: frequent rearrangement of the chromosome 11 bcl-1 locus.
|
2207314 |
1990 |