|
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
We conducted a meta-analysis to quantify the impact of CCND1/cyclin D1 amplification/overexpression on malignant transformation of head and neck PMDs.
|
31184805 |
2019 |
|
Malignant transformation
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
We discuss the functional consequences of the CCND1 gene in interplay with DNA damage response and DNA repair during malignant transformation.
|
30389156 |
2018 |
|
Malignant transformation
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Thus, increased expression of cyclin D1 and cyclin E may be involved in cell cycle progression in psoriatic epidermis, and pRb and p53 may play important roles in the prevention of malignant transformation under the hyperproliferative state in psoriasis.
|
29115643 |
2018 |
|
Malignant transformation
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
However, overexpression of cyclin D1 alone is insufficient to cause malignant transformation.
|
27894215 |
2017 |
|
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Cyclin D1 (CCND1), a key driver of malignant transformation in NSCLC, was overexpressed in many cancers, including NSCLC.
|
27988424 |
2017 |
|
Malignant transformation
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Sp1 directly binds to RBP2 promoter and enhances its expression then the upregulated RBP2 significantly increases Cyclin D1 transcription, which contributes to gastric epithelial cell malignant transformation.
|
25015565 |
2014 |
|
Malignant transformation
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Cyclin D1 is a pivotal regulator of cell cycle progression, and increased expression strongly correlates with malignant transformation.
|
20101207 |
2010 |
|
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
We investigated the clinical significance of cortactin (CTTN) and cyclin D1 (CCND1) amplification in both malignant transformation and tumour progression.
|
18991334 |
2009 |
|
Malignant transformation
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
In mantle cell lymphoma (MCL), overexpression of cyclin D1 is the hallmark of malignant transformation and results from it's juxtaposition to the immunoglobulin heavy chain enhancer.
|
19823025 |
2009 |
|
Malignant transformation
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
As cyclin D1 up-regulation is not sufficient for inducing malignant transformation, we combined DNA microarray and RNA interference (RNAi) approaches to identify novel deregulated genes involved in the progression of MCL.
|
18024791 |
2008 |
|
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
In this review, we summarize the role of cyclin D1 on tumor development and malignant transformation.
|
17359287 |
2007 |
|
Malignant transformation
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Current data indicate that cyclin D1 overexpression is not a consequence of, but rather a pivotal element in the process of malignant transformation in the lung and other tissues.
|
17070615 |
2007 |
|
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The present study also showed that recombination of BPH-1 + cyclin D1-overexpressing fibroblasts (NPF(cyclin D1)) resulted in permanent malignant transformation of epithelial cells (BPH-1(NPF-cyclin D1) cells) similar to that seen with carcinoma-associated fibroblasts (CAF).
|
17804732 |
2007 |
|
Malignant transformation
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Altered expression of cyclin D1 has been proposed as an early predictor for malignant transformation in EAC; however, the mechanisms underlying cyclin D1 deregulation have not been identified.
|
16399423 |
2005 |
|
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
An unexpected expression of galectin-3 was demonstrated in a subset of HT together with the presence of HBME-1, c-met and cyclin-D1 that are also involved in malignant transformation and deregulated cell growth.
|
15292926 |
2004 |
|
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
We conclude (1) that p16(INK4a) epigenetic inactivation most likely represents an early event, insufficient for malignant transformation, that may occur in clinically benign lesions such as LS; (2) that lack of pRb was only detected in fewer than one quarter of the carcinomas and could be considered a late secondary event; and (3) that cyclin-D1, which was overexpressed in VC and VIN, could contribute to the malignant transformation in association with p16 hypermethylation.
|
12454817 |
2002 |
|
Malignant transformation
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Evidence indicates that overexpression of cyclin D1 is an important event in malignant transformation of breast cancer cells.
|
11948404 |
2002 |
|
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
p53, but not c-Ki-ras, mutation and down-regulation of p21WAF1/CIP1 and cyclin D1 are associated with malignant transformation in gastric hyperplastic polyps.
|
11211611 |
2001 |
|
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Our analyses revealed that, in mammary epithelial cells, the Neu-Ras pathway is connected to the cell-cycle machinery by cyclin D1, explaining the absolute dependency on cyclin D1 for malignant transformation in this tissue.
|
11429595 |
2001 |
|
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Inactivation of both the pRb (pRb-cyclin D1/cyclin-dependent kinase 4/6-p16) and p53 (p53-p21(WAF1)-p14(ARF)) pathways is thought to be essential for immortalization in vitro and malignant transformation in vivo.
|
10919661 |
2000 |
|
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Since there is considerable evidence that cyclin D1 and some G protein-coupled receptors contribute to the development of specific cancers, the presence of KSHV homologs of these genes provides support for a role for KSHV in malignant transformation.
|
8892957 |
1996 |
|
Malignant transformation
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
These studies suggest that increased expression of cyclin D1 is an early event in the tumorigenic process of esophageal adenocarcinomas and that the increased expression of this gene might predispose the epithelium to malignant transformation.
|
8781742 |
1996 |
|
Malignant transformation
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
In addition, overexpression of cyclin D1 in rodent fibroblasts enhances growth and malignant transformation.
|
7898937 |
1995 |
|
Malignant transformation
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Oncogenic activity of cyclin D1 revealed through cooperation with Ha-ras: link between cell cycle control and malignant transformation.
|
8302597 |
1994 |