Impaired glucose tolerance
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Elevated serum levels of RBP4 were associated with increased risk of IR and might be useful in identifying RA at risk for IR and/or impaired glucose tolerance for early prevention strategies, especially in obese and women patients.
|
30025962 |
2019 |
Impaired glucose tolerance
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Fasting plasma levels of glycated hemoglobin, leptin, pro-insulin and retinol binding protein 4 differed between impaired fasting glucose/impaired glucose tolerance and normal subjects group and between newly detected diabetes and normal subjects group.
|
29610560 |
2018 |
Impaired glucose tolerance
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Because RBP4 is elevated in obesity and associates with the development of glucose intolerance and insulin resistance, we tested whether a liver-specific overexpression of RBP4 in mice impairs glucose homeostasis.
|
30126844 |
2018 |
Impaired glucose tolerance
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
RBP4 is produced mainly by hepatocytes.In type 2 diabetes and obesity, circulating RBP4 is increased and may act systemically to cause insulin resistance and glucose intolerance.
|
27797907 |
2017 |
Impaired glucose tolerance
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Adjustment for study group, age, BMI, waist circumference, 2 H plasma glucose, triglycerides, gamma glutamyl transferase, and insulin resistance weakened the significance of its association (OR [95%CI]: 1.65 [1.03-2.66]; P = 0.038).The results of this preliminary analyses showed that baseline serum RBP4 levels were independently associated with incident diabetes in Asian Indian men with IGT.
|
25810022 |
2015 |
Impaired glucose tolerance
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Transfer of RBP4-activated APCs into normal mice is sufficient to induce AT inflammation, insulin resistance, and glucose intolerance.
|
24606904 |
2014 |
Impaired glucose tolerance
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Prospective studies investigating the impact of RBP4 on the development of glucose intolerance are needed.
|
21617096 |
2011 |
Impaired glucose tolerance
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Plasma RBP4 was significantly elevated in impaired glucose tolerance/T2DM compared with NGT lean or obese subjects.
|
19190263 |
2009 |
Impaired glucose tolerance
|
0.100 |
Biomarker
|
phenotype |
LHGDN |
DESIGN, SETTING, PATIENTS, AND MAIN OUTCOME MEASURES: We measured the plasma concentrations of retinol-binding protein-4 (RBP4), transthyretin (TTR), and adiponectin and metabolic parameters in four groups of women who exhibited normal glucose tolerance (NGT) during a previous pregnancy (NP, n = 17), NGT after GDM (GDM-NGT, n = 72), impaired glucose tolerance after GDM (GDM-IGT, n = 60), and type 2 diabetes after GDM (GDM-DM, n = 8).
|
18492757 |
2008 |
Impaired glucose tolerance
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
RBP4 mRNA levels in adipose tissue and muscle of nondiabetic human subjects with either normal or impaired glucose tolerance (IGT) were studied, along with plasma RBP4.
|
17595259 |
2007 |
Impaired glucose tolerance
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Vis fat RBP4 mRNA was increased approximately 60-fold and 12-fold in Vis and SC obese subjects respectively versus lean subjects, and approximately 2-fold with impaired glucose tolerance/T2D subjects versus normoglycemic subjects.
|
17618858 |
2007 |