BCL2, BCL2 apoptosis regulator, 596

N. diseases: 1456; N. variants: 27
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0024305
Disease: Lymphoma, Non-Hodgkin
Lymphoma, Non-Hodgkin 		0.600 GeneticVariation disease UNIPROT
CUI: C0024299
Disease: Lymphoma
Lymphoma 		0.500 Biomarker group HPO
CUI: C0024299
Disease: Lymphoma
Lymphoma 		0.500 GenomicAlterations group CGI
CUI: C0431692
Disease: Bilateral renal hypoplasia
Bilateral renal hypoplasia 		0.200 Biomarker disease MGD
CUI: C0431694
Disease: Oligomeganephronic hypoplasia of kidney
Oligomeganephronic hypoplasia of kidney 		0.200 Biomarker disease MGD
CUI: C0015967
Disease: Fever
Fever 		0.180 Biomarker phenotype HPO
CUI: C0015672
Disease: Fatigue
Fatigue 		0.120 Biomarker phenotype HPO
CUI: C0024236
Disease: Lymphedema
Lymphedema 		0.100 Biomarker disease HPO
CUI: C0025289
Disease: Meningitis
Meningitis 		0.100 Biomarker disease HPO
CUI: C0028081
Disease: Night sweats
Night sweats 		0.100 Biomarker phenotype HPO
CUI: C0032227
Disease: Pleural effusion disorder
Pleural effusion disorder 		0.100 Biomarker group HPO
CUI: C0037287
Disease: Skin nodule
Skin nodule 		0.100 Biomarker disease HPO
CUI: C0038002
Disease: Splenomegaly
Splenomegaly 		0.100 Biomarker phenotype HPO
CUI: C0520743
Disease: Mediastinal lymphadenopathy
Mediastinal lymphadenopathy 		0.100 Biomarker disease HPO
CUI: C1262477
Disease: Weight decreased
Weight decreased 		0.100 Biomarker phenotype HPO
CUI: C4025698
Disease: Abnormality of the peritoneum
Abnormality of the peritoneum 		0.100 Biomarker disease HPO
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.600 Therapeutic disease RGD "Xiusanzhen" can regulate the expression of hippocampal Bcl-2 and Bax proteins in AD rats, which may contribute to its clinical effect in relieving AD, and the therapeutic effect depends on the integrity of the olfactory nerve pathway. 21585051 2011
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 AlteredExpression group BEFREE <b>96</b> inhibited xenografts growth by reducing the expression of TNF-α and Bcl-2 in the tumour tissue. 31288582 2019
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas 		0.100 Biomarker group BEFREE <b>Abbreviations used:</b> AO: acridine orange; Bcl-2: B cell lymphoma 2. cDNA: complementary DNA; ELISA: enzyme linked immunosorbent assay; EB: ethidium bromide; IC50: the half maximal inhibitory concentration; mRNA: messenger RNA. 28539722 2019
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas 		0.100 Biomarker group BEFREE <b>Abbreviations used:</b> MTT: Thiazolyl blue tetrazolium blue; DMSO: Dimethyl sulfoxide; BSA: Bovine serum albumin; DMEM: Dulbecco's minimum essential medium; NCCS: National Centre for Cell Science; PBS: Phosphate-Buffered Saline; HepG2: Liver hepatocellular carcinoma; HeLa: Henrietta Lacks cervical carcinoma cells; HCT-116: Human colorectal carcinoma cell line; EAC: Ehrlich ascites carcinoma cells; IC50: Half maximal inhibitory concentration; AO/EB: Acridine orange/Ethidium bromide; BCL-2: B-cell lymphoma 2; BCL-XL: B-cell lymphoma-extra large; MCL-1: Myeloid cell leukemia 1; PDB: Protein Data Bank; ANOVA: Analysis of variance. 29491636 2018
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia 		0.500 Biomarker disease BEFREE <b>Abbreviations:</b> ESCs: endometrial stromal cells; 17β-E2: 17β-Estradiol; EMT: epithelial-mesenchymal transition; CASP3: caspase 3; BCL2: B cell leukemia/lymphoma 2; VEGFA: vascular endothelial growth factor A; lncRNA: long non-coding RNA; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; RT-qPCR: reverse transcription-quantitative polymerase chain reaction. 30608887 2019
CUI: C2004493
Disease: Leukemia, B-Cell
Leukemia, B-Cell 		0.100 Biomarker disease BEFREE <b>Abbreviations:</b> ESCs: endometrial stromal cells; 17β-E2: 17β-Estradiol; EMT: epithelial-mesenchymal transition; CASP3: caspase 3; BCL2: B cell leukemia/lymphoma 2; VEGFA: vascular endothelial growth factor A; lncRNA: long non-coding RNA; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; RT-qPCR: reverse transcription-quantitative polymerase chain reaction. 30608887 2019
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia 		0.500 Biomarker disease BEFREE <b>Background:</b> B-cell leukemia/lymphoma-2 (BCL-2) protein is an important part of apoptotic pathway, which is overexpressed in chronic lymphocytic leukemia cells, non-Hodgkin lymphoma cells, and myeloma cells. 31293422 2019
CUI: C2004493
Disease: Leukemia, B-Cell
Leukemia, B-Cell 		0.100 Biomarker disease BEFREE <b>Background:</b> B-cell leukemia/lymphoma-2 (BCL-2) protein is an important part of apoptotic pathway, which is overexpressed in chronic lymphocytic leukemia cells, non-Hodgkin lymphoma cells, and myeloma cells. 31293422 2019
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.100 Biomarker disease BEFREE <b>Conclusion:</b> HEATR1 inhibition activated p53 by reducing ribosome biogenesis, which subsequently led to NSCLC cell apoptosis and reduced cell survival through the p53-PUMA-BAX/BCL2 axis. 31190896 2019