|
Squamous cell carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
This cytotoxicity resulted from TTO induced apoptosis in both A-375 and HEp-2 cell lines as evidenced by morphological features of apoptosis and Annexin V/PI staining results in addition to the activation of caspase-3/7 and -9, upregulation of pro-apoptotic genes (P53 and BAX) and downregulation of the anti-apoptotic gene BCL-2.
|
30599074 |
2019 |
|
Squamous cell carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Our data suggest that the PI3K/AKT pathway is related to cell survival and proliferation in oral squamous cell carcinoma through its interaction with Bcl-2 family members.<br />.
|
31759362 |
2019 |
|
Squamous cell carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Long non-coding RNA CEBPA-AS1 correlates with poor prognosis and promotes tumorigenesis via CEBPA/Bcl2 in oral squamous cell carcinoma.
|
29281558 |
2018 |
|
Squamous cell carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The stepwise progression of AK, with increased expression of anti-apoptotic Bcl-2, favors progression to SCC.
|
30222011 |
2018 |
|
Squamous cell carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
miR-34a targets BCL-2 to suppress the migration and invasion of sinonasal squamous cell carcinoma.
|
30405796 |
2018 |
|
Squamous cell carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The elevated activation of NFκB and AP-1 is correlated with differential regulation of Bcl-2 and associated with oral squamous cell carcinoma progression and resistance.
|
28233171 |
2017 |
|
Squamous cell carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
E-cadherin-mediated impairment increases anti-apoptotic mechanism through upregulation of Bcl-2: An immunohistochemical study in various patterns of invasion of oral squamous cell carcinoma.
|
28294427 |
2017 |
|
Squamous cell carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Pro-apoptotic BAX expression was increased, whereas antiapoptotic BCL-2 expression was decreased in BmKn-2 exposed HSC4 and KB cells.
|
27780132 |
2016 |
|
Squamous cell carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The luciferase assay demonstrated that PDF could significantly suppress Bcl-2 transcriptional activation in human laryngeal squamous carcinoma cells (Hep-2) cells.
|
26923693 |
2016 |
|
Squamous cell carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
A direct statistically significant association was detected between c-erb-B2 expression and Bcl-2 and p53 expression in TCC and SCC specimens.
|
26653553 |
2015 |
|
Squamous cell carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
The goal of our study was a comparative evaluation of apoptosis regulators: p53, Bcl-2, Bax, COX-2, and survivin in lung adenocarcinoma (AC) and squamous cell carcinoma (SCC).
|
26022894 |
2015 |
|
Squamous cell carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
MicroRNA-21 (miR-21) regulates cellular proliferation, invasion, migration, and apoptosis by targeting PTEN, RECK and Bcl-2 in lung squamous carcinoma, Gejiu City, China.
|
25084400 |
2014 |
|
Squamous cell carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
The immunoexpression of survivin, Ki67 and Bcl-2 was significantly higher in SNCs than in sinonasal IPs and control group.
|
24203629 |
2013 |
|
Squamous cell carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Mcl-1 and FBW7 control a dominant survival pathway underlying HDAC and Bcl-2 inhibitor synergy in squamous cell carcinoma.
|
23274910 |
2013 |
|
Squamous cell carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
B-cell lymphoma 2 (Bcl-2) is an antiapoptotic protein that is overexpressed in head and neck squamous cell carcinomas, which has been implicated in development of radio- and chemoresistance.
|
23734725 |
2013 |
|
Squamous cell carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Bax, Bcl-2 and Bcl-XL protein expression was quantified using fluorescent IHC and AQUA technology in normal oral cavity squamous epithelium (OCSE) and OSCC tumour samples.
|
22852863 |
2012 |
|
Squamous cell carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
We have previously shown that head and neck tumors exhibit significantly higher Bcl-2 expression in tumor-associated endothelial cells and overexpression of Bcl-2 alone in tumor-associated endothelial cells was sufficient to enhance tumor metastasis of oral squamous cell carcinoma in a severe combined immunodeficient (SCID) mouse model.
|
21976712 |
2011 |
|
Squamous cell carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Bcl-2 overexpression induces a partial epithelial to mesenchymal transition and promotes squamous carcinoma cell invasion and metastasis.
|
20145039 |
2010 |
|
Squamous cell carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Bcl-2 staining was weak to moderate in OLP, and moderate to intense in SCC.
|
20658736 |
2010 |
|
Squamous cell carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
High-risk human papillomavirus (HPV) is not associated with p53 and bcl-2 expression in oral squamous cell carcinomas.
|
19124208 |
2009 |
|
Squamous cell carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Both SC and NSC showed higher level of p53, bcl-2, ki-67, and EGFR than in CTL group while p16, Rb, and c-myc were not different. p53 was associated with high grade SCC in both SBT and NSBT.
|
19243595 |
2009 |
|
Squamous cell carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Suprabasal expression of BCL-2 in skin does not increase the formation of papillomas or their malignant progression to squamous cell carcinomas in two-stage mouse skin carcinogenesis.
|
19035317 |
2008 |
|
Squamous cell carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Bcl-2 expression in oral squamous cell carcinoma.
|
17404013 |
2007 |
|
Squamous cell carcinoma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Mutational analysis of the BH3 domains of proapoptotic Bcl-2 family genes Bad, Bmf and Bcl-G in laryngeal squamous cell carcinomas.
|
17557568 |
2007 |
|
Squamous cell carcinoma
|
0.300 |
GeneticVariation
|
disease |
LHGDN |
Single-nucleotide polymorphisms at the TP53-binding or responsive promoter regions of BAX and BCL2 genes and risk of squamous cell carcinoma of the head and neck.
|
17693666 |
2007 |