B-Cell Lymphomas
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Furthermore, morin was able to down regulate the levels of inflammatory and apoptotic markers such as nuclear factor kappa B (NF-κB), neuronal nitric oxide synthase (nNOS), tumor necrosis factor-α (TNF-α), p53, cysteine aspartate specific protease-3 (caspase-3) and B-cell lymphoma-2 (Bcl-2).
|
31722249 |
2020 |
B-Cell Lymphomas
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Meanwhile, ACART increased the expression of the B cell lymphoma 2 (Bcl-2) and suppressed the expression of Bcl-2-associated X (Bax) and cytochrome-C (Cyt-C).
|
31749326 |
2020 |
B-Cell Lymphomas
|
0.100 |
Biomarker
|
group |
BEFREE |
Compound 7a notably inhibited the expression and activity of PIM kinases, as evidenced by reduced B‑cell lymphoma‑2 (Bcl‑2)‑associated death promoter phosphorylation at Ser112.
|
31789392 |
2020 |
B-Cell Lymphomas
|
0.100 |
Biomarker
|
group |
BEFREE |
After 30 min of ischemia and 120 min of reperfusion, cardiac function, infarct size, cardiac marker enzymes, antioxidative parameters, inflammatory factors, histopathological changes, cardiomyocyte apoptosis, and B‑cell lymphoma 2 (Bcl‑2), Bcl‑2‑associated X protein and caspase‑3 expression were determined using a multi‑channel physiological recording system, nitrotetrazolium blue chloride, biochemical kits, radioimmunoassay kits, hematoxylin and eosin, terminal deoxynucleotidyl‑transferase‑mediated dUTP nick end labeling assay, immunohistochemistry and reverse transcription‑quantitative PCR, respectively.
|
31789417 |
2020 |
B-Cell Lymphomas
|
0.100 |
AlteredExpression
|
group |
BEFREE |
As a result, we observed higher level of XIST and Smurf1, but lower level of miR-27a in SCI rats and lipopolysaccharide (LPS)-induced primary microglial cells. in vitro, LPS induced SCI microglia cells as described by decreased cell viability and B cell lymphoma 2 (Bcl-2) expression, and increased cell apoptosis rate, Bax and cleaved caspase 3 levels, and tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6) secretions. in vivo, a T10 laminectomy caused SCI rats as evidenced by decreased Basso-Beattie-Bresnahan Locomotor Rating Scale (BBB) score and induced expression of Bax, cleaved caspase 3, TNF-α and IL-6.
|
31778769 |
2020 |
B-Cell Lymphomas
|
0.100 |
Biomarker
|
group |
BEFREE |
<i>MYC/BCL2</i> DHL, <i>MYC/BCL6</i> DHL and MYC/BCL2 DEL are an aggressive B cell lymphoma and patients have a poor prognosis.
|
31615842 |
2020 |
B-Cell Lymphomas
|
0.100 |
Biomarker
|
group |
BEFREE |
Western blot analysis was used to investigate the effect of DPM on B-cell lymphoma 2 (Bcl-2), Bcl-2-associated X protein (Bax) and cleaved caspase-3.
|
31553997 |
2020 |
B-Cell Lymphomas
|
0.100 |
Biomarker
|
group |
BEFREE |
The levels of Shrm4, GABA<sub>B1</sub>, Bcl-2-associated protein x (Bax), B cell lymphoma 2 (Bcl-2), cleaved Caspase-3, microtubule-associated protein 2 (MAP-2) as well as suppressor of cytokine signaling 2 (SOCS2) were detected to further assess the role of Shrm4 and GABA pathway in NSCs.
|
31654185 |
2020 |
B-Cell Lymphomas
|
0.100 |
Biomarker
|
group |
BEFREE |
The effects of AST were mediated through the downregulation of Bcl-2 associated X, apoptosis regulator (Bax), and cleaved caspase-3 and through the upregulation of B-cell lymphoma 2 (Bcl-2).
|
31566218 |
2020 |
B-Cell Lymphomas
|
0.100 |
Biomarker
|
group |
BEFREE |
We found that ectopic expression of gga-miR-16-5p in DF-1 cells enhanced IBDV-induced apoptosis by directly targeting cellular anti-apoptotic protein B-cell lymphoma-2 (Bcl-2), facilitating IBDV replication in DF-1 cells.
|
31694944 |
2020 |
B-Cell Lymphomas
|
0.100 |
GeneticVariation
|
group |
BEFREE |
B-cell lymphoma-extra large (Bcl-X<sub>L</sub>) is one of the anti-apoptotic proteins of the Bcl-2 family that is localized in the mitochondria.
|
31734345 |
2020 |
B-Cell Lymphomas
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Western blot assay was conducted to examine the protein levels of B-cell lymphoma-2 (Bcl-2), BCL2-Associated X (Bax), matrix metalloprotein 2 (MMP2), MMP9 and PDCD4.
|
31760170 |
2020 |
B-Cell Lymphomas
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Downstream molecular mechanisms, including SRY-box transcription factor 6 (SOX6), extracellular regulated protein kinases (ERK), Cyclin D1, B-cell lymphoma-2 (BCL-2) and BCL2 associated X, apoptosis regulator (BAX), were determined by western blot.
|
31609809 |
2020 |
B-Cell Lymphomas
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The current study sought to investigate the effect of modified exosome-containing plasmids expressing B-cell lymphoma-2 (Bcl-2) and Bcl-2-associated X-protein (Bax) short hairpin RNA (shRNA) on apoptosis and neural functions after TBI.
|
29762232 |
2020 |
B-Cell Lymphomas
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In addition, modulation of ZEB1 and subsequent change in MRP4 expression correlated with a lower apoptotic response to docetaxel, characterized by lower B-cell lymphoma 2 (Bcl2), high BCL2-associated X protein (Bax), and high active caspase 3 expression.
|
30880686 |
2020 |
B-Cell Lymphomas
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Ocimum basilicum L. significantly decreased testicular levels of nuclear factor-kappa B and B-cell lymphoma-2 (Bcl2)-associated protein X, along with caspase-3 immunohistochemical staining.
|
31667861 |
2020 |
B-Cell Lymphomas
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The protein levels of B-cell lymphoma-2 (Bcl-2), Bcl-2-associated X (Bax), X-linked inhibitor of apoptosis (XIAP), total poly (ADP-ribose) polymerase (PARP), caspase-3 and caspase-8 were examined using western blotting.
|
31586690 |
2020 |
B-Cell Lymphomas
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Furthermore, CP group showed toxic histopathological changes of marked cardiac damage in addition to a significant decrease in total antioxidant capacity (TAC), superoxide dismutase (SOD), eNOS gene expression, and B cell lymphoma 2 (Bcl2) immunoexpression.
|
31230218 |
2020 |
B-Cell Lymphomas
|
0.100 |
Biomarker
|
group |
BEFREE |
CABYR-a/b downregulation suppressed cell proliferation and induced G1-phase arrest via decreasing cyclin D1 and cyclin dependent kinase 4, while promoted apoptosis by reducing B-cell lymphoma 2 (Bcl-2) and increasing Bcl-2-associated death promoter.
|
31692072 |
2020 |
B-Cell Lymphomas
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Diabetes-related physical and biochemical parameters, pancreatic histopathological changes, immunohistochemical staining, quantitative real-time polymerase chain reaction, and western blot were used to measure the expression of apoptosis signal-regulating kinase 1 (ASK1), Jun N-terminal kinase (JNK), Bcl-2 associated X protein (BAX), and B-cell lymphoma-2 (Bcl-2).
|
31411368 |
2020 |
B-Cell Lymphomas
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The mRNA and protein expression of apoptosis-related genes including Caspase-3, Caspase-9, Caspase-8, Cytochrome-C (Cyt-C), p53, B-cell lymphoma 2 (Bcl-2) and Bcl-2 associated X protein (Bax) were significantly altered in broilers BF.
|
31841897 |
2020 |
B-Cell Lymphomas
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Furthermore, exposure to Pb induced neurodegenerative cognitive impairment in rats, depressed the long-term potentiation (LTP) in the rat brain slices, increased the neuronal intracellular free calcium concentration ([Ca<sup>2+</sup>]i), inhibited the phosphorylation of Ca<sup>2+</sup>/calmodulin-dependent protein kinase II (CaMKII) and cyclic adenosine 3',5'-monophosphate (cAMP) response element binding protein (CREB) as well as the expression of anti-apoptotic protein B-cell lymphoma 2 (Bcl2), and activated the phosphorylation of extracellular regulated protein kinases (Erk) protein both in vitro and in vivo.
|
31710906 |
2020 |
B-Cell Lymphomas
|
0.100 |
Biomarker
|
group |
BEFREE |
The potential protective effects of resveratrol (RES) on the modulation of hepatic biomarkers of apoptosis and survival, p53-Bax axis, and B-cell lymphoma 2 (Bcl-2) in an animal model of paracetamol-induced acute liver injury have not been investigated before.
|
31554003 |
2020 |
B-Cell Lymphomas
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Aβ<sub>25-35</sub> -induced changes in Ca<sup>2+</sup> and B-cell lymphoma-2 (Bcl-2) and Bcl-2-associated X (Bax) protein and gene levels in cells were also reversed by genistein.
|
30450837 |
2019 |
B-Cell Lymphomas
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Phase 1 study of lenalidomide plus dose-adjusted EPOCH-R in patients with aggressive B-cell lymphomas with deregulated MYC and BCL2.
|
30707764 |
2019 |