Acute leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we further evaluated the antitumor activity of LS-007 alone and in combination with a Bcl-2 inhibitor ABT-199 in acute leukemia (AL) cells.
|
27569395 |
2016 |
Acute leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our study provides new insights into the mechanisms of acquired resistance of Bcl-2 and MDM2 inhibitors in acute leukemia models and suggests that certain sequential or combination treatment of these two distinct classes of apoptosis-inducing agents should be tested as new treatment strategies for acute leukemia in the clinic.
|
25754349 |
2015 |
Acute leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study aimed to investigate the expression of drug resistance (MDR1, MRP1, LRP, BCRP, GSTP1, DHFR) and apoptotic genes (p53, BCL-2, Survivin) in adult acute leukemias and compare them with clinical and hematological findings and response to induction chemotherapy.
|
22037714 |
2012 |
Acute leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Targeting of Bcl-2 family proteins for treatment of acute leukaemia.
|
21869449 |
2011 |
Acute leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, transcription of hsp70.1 and Bcl-2 producing anti-apoptotic proteins was not affected in acute leukaemia.
|
19020783 |
2008 |
Acute leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In addition, we analyzed BNIP3 mutation in the DNA sequences encoding BH3 (Bcl-2 homology3) and TM (transmembrane) domains that are important in the cell death function of BNIP3 by single-strand conformation polymorphism (SSCP) in 48 colorectal, 48 gastric, and 48 breast carcinomas, and 48 acute leukemias.
|
18092960 |
2007 |
Acute leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Abnormalities of the P53, MDM2, BCL2 and BAX genes in acute leukemias.
|
16059649 |
2005 |
Acute leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The aim of this study was to determine the levels of Bcl-2 and Fas expression on blast cells from patients with acute leukemia and to correlate the degree of expression to the clinical and laboratory prognostic factors and the patient's outcome.
|
15203866 |
2004 |
Acute leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We analysed by immunocytochemistry the expression of p53, bcl-2 and ras proteins in bone marrow blasts from 59 patients with acute leukaemia (AL), 36 myeloid (AML) and 23 lymphoid (ALL), and from 22 patients with myelodysplastic syndrome (MDS); our aim was to examine if abnormalities in their expression were associated with peculiar biological and clinical findings, or with an altered apoptosis rate, as measured by TUNEL technique.
|
11699413 |
2001 |
Acute leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Absolute levels of MDR-1, MRP, and BCL-2 MRNA and tumor remission in acute leukemia.
|
10500792 |
1999 |
Acute leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Low BCL-2 expression in acute leukemia with t(8;21) chromosomal abnormality.
|
10086726 |
1999 |
Acute leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Bcl-2 gene and its family genes Bax, Bcl-Xl as well as Fas/Apo-1 and their clinical significance in acute leukemia.
|
11245018 |
1998 |
Acute leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Bcl-2 expression and prognosis in childhood acute leukemia. Children's Cancer and Leukemia Study Group.
|
9592841 |
1998 |
Acute leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, mutations within the (u)ORFs of bax and bcl-2 that (in)activate or deregulate Bax and Bcl-2 are infrequent in primary childhood acute leukaemia and do not play a major role in regulation of the encoded proteins in this disease.
|
9645350 |
1998 |
Acute leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
More detailed investigations of the molecular mechanisms involved in the intracellular apoptotic signal transduction, such as interactions of the bcl-2 and the other members of the bcl-2 family, and functionality of the interleukin-1beta converting enzyme (ICE) like-proteases, may give new insights into key events responsible for the resistance or sensitivity to the induction of apoptosis in acute leukemia.
|
9264377 |
1997 |