BCL2, BCL2 apoptosis regulator, 596
N. diseases: 1456; N. variants: 27
Source: ALL
| Disease | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year |
|---|---|---|---|---|---|---|---|
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0.100 | AlteredExpression | disease | BEFREE | Helicobacter pylori was determined to increase apoptosis (49.3% vs. 25.7%, p<0.05), nevertheless, it had no significant effect on proliferation and Bcl-2 expression. | 22277792 | 2012 |
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0.100 | AlteredExpression | disease | BEFREE | Co-incubation of epithelial cells with Hp, without or with CagA increased Bax expression and simultaneously decreased expression for Bcl-2. | 22610150 | 2012 |
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0.100 | AlteredExpression | disease | BEFREE | Evidence suggests that the carcinogenic process guided by Helicobacter pylori is related to the expression of cell cycle and apoptosis proteins as BCL-2, BAX, and MYC. | 21538123 | 2011 |
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0.100 | AlteredExpression | disease | BEFREE | The aim of the present study is to evaluate the influence of Helicobacter pylori on Bax and Bcl-2 mRNA and protein levels in patients with chronic gastritis and gastric cancer. | 19160045 | 2010 |
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0.100 | AlteredExpression | disease | BEFREE | To investigate the effect of Helicobacter pylori (H pylori) infection on the expressions of Bcl-2 family members in gastric adenocarcinoma. | 14716828 | 2004 |
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0.100 | AlteredExpression | disease | BEFREE | Helicobacter pylori induced apoptosis in gastric epithelial cells is mediated by altered expression of the products of the Bcl-2, Bax, and c-Myc genes. | 12560457 | 2003 |
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0.100 | Biomarker | disease | BEFREE | NF-kappaB and Bcl-2 in Helicobacter pylori-induced apoptosis in gastric epithelial cells. | 15033793 | 2003 |
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0.100 | Biomarker | disease | BEFREE | Furthermore the level of hTERT mRNA in GC with H.pylori infection (47/48) was higher than that without infection (30/36), however the relationship between bcl-2 and H.pylori was only in IMIII. | 12508351 | 2003 |
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0.100 | Biomarker | disease | BEFREE | 1) Colorectal carcinoma and its resection margin overexpress gastrin and receptors for gastrin (CCK(B)-R), and COX-2; 2) here, we propose that an increased plasma level of gastrin should be considered as suitable biomarker of colorectal cancer, 3) HP infection may contribute to colonic cancerogenesis by enhancing expression of gastrin and COX-2, they may account for stimulation of the tumor growth, angiogenesis and reduction in apoptosis as evidenced an increased ratio of mRNA expression for anti-apoptotic Bcl2 over proapoptotic Bax proteins and 4) HP positive patients who develop colorectal cancer should be subjected to the HP eradication; this is expected to reduce hypergastrinemia and to attenuate COX-2 expression. | 11687726 | 2002 |
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0.100 | AlteredExpression | disease | BEFREE | Expression of bcl-2 in autoimmune and Helicobacter pylori-associated atrophic gastritis. | 10219822 | 1999 |