|
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
MiRNA-mRNA network and mRNA-mRNA network analysis showed that hsa-miR-320a, hsa-miR-331-3p, hsa-miR-26a-5p, hsa-miR-196a-5p, hsa-miR-221-3p, coiled-coil domain containing 180 (CCDC180), melanoma antigen gene family member D1 (MAGED1), membrane spanning 4-domains A7 (MS4A7), hephaestin like 1 (HEPHL1), BH3 (Bcl-2 homology 3)-like motif containing, cell death inducer (BLID), matrix metallopeptidase 13 (MMP13), guanylate binding protein 5 (GBP5), adipogenesis regulatory factor (ADIRF), formin homology 2 domain containing 1 (FHDC1), protein kinase CAMP-dependent type II regulatory subunit beta (PRKAR2B), nodium leak channel, non-selective (NALCN), myosin light chain kinase 3 (MYLK3), epidermal growth factor receptor (EGFR) and zinc finger protein 704 (ZNF704) were key miRNAs and genes in the malignant transformation induced by MC-LR in L02 cells.
|
29518473 |
2018 |
|
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
For human B-cell subsets, the functional relationships among BCL-2 members are unclear, and also if and how they shift after malignant transformation.
|
27689871 |
2017 |
|
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The role of Bcl-2 in malignant transformation and tumorigenesis was confirmed by gene silencing experiments using human lung carcinoma NCI-H460 cells.
|
22666341 |
2012 |
|
Malignant transformation
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Bcl-2 expression and its possible influence on malignant transformation of oral lichen planus.
|
20658736 |
2010 |
|
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Interestingly, NO-mediated S-nitrosylation and stabilization of Bcl-2 protein was the primary mechanism involved in the malignant transformation of nontumorigenic lung epithelial cells in response to long-term carcinogen exposure.
|
20716276 |
2010 |
|
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Nitric oxide-mediated bcl-2 stabilization potentiates malignant transformation of human lung epithelial cells.
|
19556603 |
2010 |
|
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Bcl-xL, a member of Bcl-2 protein family functioned as dominant regulators of apoptotic cell death, has been reported to play important roles in malignant transformation and tumor development.
|
20580954 |
2010 |
|
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
These findings indicated that Deleted in pancreatic carcinoma locus 4 might be an important biomarker for malignant transformation and be involved in inducing apoptosis by modulating Bcl-2/Bax balance.
|
18620728 |
2008 |
|
Malignant transformation
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
It is unknown whether the anti-apoptotic activity of BCL-2 is involved in the susceptibility of this cell type to malignant transformation.
|
19035317 |
2008 |
|
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Bcl-2 and clusterin genes have been related to the inhibition of apoptosis, an event that plays a key role in malignant transformation and in invasive disease.
|
16675913 |
2006 |
|
Malignant transformation
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Our findings show that p53, Bax, Bcl-2 and Mdm2 mRNA expression levels correlate with the malignant transformation of the uterine cervix. mRNA coexpression patterns of the members of the pro- and anti-apoptotic family examined in cervical carcinogenesis were found to be disrupted in CIN and cancer, as already demonstrated at the protein level.
|
15832769 |
2005 |
|
Malignant transformation
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
The frequent expression of Bcl-2 in oral leukoplakia with malignant transformation combined with the reduction in the number of apoptotic cells indicated that malignancy occurred as a result of the avoidance of apoptosis.
|
12953781 |
2003 |
|
Malignant transformation
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Taken together, SHEE85 cells were in fully malignant transformation and their molecular mechanism involved the expression of cellular genes, such as p53, bcl-2, c-myc and ras, and aberrance of chromosomes.
|
12851721 |
2003 |
|
Malignant transformation
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Previous studies on peritoneal plasmacytomas (PCTs) in BALB/c (C) mice suggested that the enforced expression of the death repressor BCL2 in B cells might facilitate the malignant transformation of aberrant B cells containing Myc-activating T(12;15) translocations, generating an improved model of plasmacytomagenesis.
|
14695177 |
2003 |
|
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
These data suggest that the cooperation of BARF1 with Bcl-2 is essential for the induction of malignant transformation.
|
11313861 |
2001 |
|
Malignant transformation
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Up-regulation of PTHrP and Bcl-2 characterizes malignant transformation of osteochondroma because PTHrP and Bcl-2 expression is significantly higher in borderline and grade I peripheral chondrosarcomas compared with osteochondromas.
|
11140704 |
2000 |
|
Malignant transformation
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Two (8%) were immunoreactive for p53, one of which recurred and one of which underwent MT. bcl-2 expression was observed in 9 (37%) of the IMTs, with no difference among the three groups.
|
10102613 |
1999 |
|
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Here we report that BCL-2 protein expression of human glial tumors in vivo correlates with malignant transformation in that BCL-2 immunoreactive glioma cells were more abundant in WHO grade III/IV gliomas than in grade I/II gliomas.
|
7539458 |
1995 |