REL, REL proto-oncogene, NF-kB subunit, 5966

N. diseases: 90; N. variants: 5
Disease: Arthritis, Psoriatic ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0003872
Disease: Arthritis, Psoriatic
Arthritis, Psoriatic 		0.030 Biomarker disease BEFREE Several genetic factors involved in the susceptibility to psoriasis and psoriatic arthritis (PsA) have been identified with genome-wide association studies, including human leukocyte antigen (HLA)-C, junction adhesion molecule 2 (JAM2) and REL. 24566686 2014
CUI: C0003872
Disease: Arthritis, Psoriatic
Arthritis, Psoriatic 		0.030 GeneticVariation disease BEFREE However, conditional analysis indicated that rs13017599, rather than rs702873, accounts for the PsA association at REL. 22170493 2012
CUI: C0003872
Disease: Arthritis, Psoriatic
Arthritis, Psoriatic 		0.030 Biomarker disease BEFREE The REL gene, a key modulator of the NFκB pathway, is associated with PsA but the allele conferring risk to RA is protective in PsA suggesting that there are fundamental differences in the aetiological mechanisms underlying these two types of inflammatory arthritis. 22328738 2012