RELA, RELA proto-oncogene, NF-kB subunit, 5970

N. diseases: 483; N. variants: 11
Disease: Malignant tumor of colon ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.340 AlteredExpression disease BEFREE Mechanistically, PHD2 overexpression obviously suppressed NF-κB activity through decreasing phosphorylated IκB-α while increasing cytoplasmic NF-κB p65 levels in colon cancer. 31838134 2020
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.340 GeneticVariation disease BEFREE We found that positive expression of DDA1 alone or in combination with p65 nuclear translocation correlated with increased risk of tumor recurrence in patients with stage IIB-IIC colon cancer. 26942699 2016
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.340 Biomarker disease BEFREE The regulation reported in p65 subunit in HT29 treated with St John's Wort and in PC3 treated with thyme might point to the NF-κB as the molecular target underlying the effect of these infusions. 24001836 2014
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.340 Biomarker disease CTD_human NADPH oxidase overexpression in human colon cancers and rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). 20715105 2011
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.340 AlteredExpression disease BEFREE Furthermore, CDX2 was found to co-immunoprecipitate with the p65 subunit of NF-kappaB and to inhibit p65-induced NF-kappaB minimal promoter activity in colon cancer cells. 15013430 2004