Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.320 Biomarker disease BEFREE The skeletal renin-angiotensin system plays key role in the pathological process of osteoporosis. 26439241 2016
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.320 AlteredExpression disease BEFREE Activation of renin-angiotensin system induces osteoporosis independently of hypertension. 18847324 2009
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.320 Biomarker disease CTD_human Activation of renin-angiotensin system induces osteoporosis independently of hypertension. 18847324 2009
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.320 Biomarker disease CTD_human Using a chimeric RAS model of transgenic THM (Tsukuba hypertensive mouse) expressing both the human renin and human angiotensinogen genes, we showed in this study that activation of RAS induces high turnover osteoporosis with accelerated bone resorption. 18847324 2009
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.320 Biomarker disease CTD_human Transgenic mice that express only the human renin gene were normotensive and yet exhibited a low bone mass, suggesting that osteoporosis occurs independently of the development of hypertension per se. 18847324 2009