ACTB, actin beta, 60

N. diseases: 1110; N. variants: 39
Disease: Neuropil Threads ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0521175
Disease: Neuropil Threads
Neuropil Threads 		0.010 Biomarker disease BEFREE The requirement of activated ADF/cofilin for the sequestration of pMAP suggests that neuropil thread structures in the AD brain may be initiated by elevated cofilin activation and F-actin bundling that can be caused by oxidative stress, mitochondrial dysfunction, or Abeta peptides, all suspected initiators of synaptic loss and neurodegeneration in AD. 19828813 2009