|
Colorectal Carcinoma
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
We identified RHEB and mTOR as upregulated genes in CRC.
|
31332784 |
2020 |
|
Colorectal Carcinoma
|
0.310 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Non-Small Cell Lung Carcinoma
|
0.300 |
Biomarker
|
disease |
CTD_human |
Ras homologue enriched in brain is a critical target of farnesyltransferase inhibitors in non-small cell lung cancer cells.
|
20554106 |
2010 |
|
Hemimegalencephaly
|
0.110 |
GeneticVariation
|
disease |
BEFREE |
This is the first report of a somatic mutation in RHEB gene in a patient suffering from Epilepsy secondary to Hemimegalencephaly.
|
30414531 |
2019 |
|
Drug Resistant Epilepsy
|
0.110 |
GeneticVariation
|
disease |
BEFREE |
Identification of a somatic mutation in the RHEB gene through high depth and ultra-high depth next generation sequencing in a patient with Hemimegalencephaly and drug resistant Epilepsy.
|
30414531 |
2019 |
|
Renal Cell Carcinoma
|
0.110 |
GeneticVariation
|
disease |
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
|
Renal Cell Carcinoma
|
0.110 |
Biomarker
|
disease |
BEFREE |
Point mutations of the mTOR-RHEB pathway in renal cell carcinoma.
|
26255626 |
2015 |
|
Hemimegalencephaly
|
0.110 |
GeneticVariation
|
disease |
CLINVAR |
|
|
|
|
Drug Resistant Epilepsy
|
0.110 |
GeneticVariation
|
disease |
CLINVAR |
|
|
|
|
Malignant Uterine Corpus Neoplasm
|
0.100 |
GeneticVariation
|
disease |
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
|
Transitional cell carcinoma of bladder
|
0.100 |
GeneticVariation
|
disease |
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
|
Papillary renal cell carcinoma, sporadic
|
0.100 |
GeneticVariation
|
disease |
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
|
Tuberous Sclerosis
|
0.030 |
Biomarker
|
disease |
BEFREE |
Whereas growth factors inhibit the tuberous sclerosis complex (TSC1-TSC2), a negative Rheb regulator, the role of AAs in Rheb activation remains unknown.
|
25816988 |
2015 |
|
Tuberous Sclerosis
|
0.030 |
Biomarker
|
disease |
LHGDN |
Structural basis for the unique biological function of small GTPase RHEB.
|
15728574 |
2005 |
|
Tuberous Sclerosis
|
0.030 |
Biomarker
|
disease |
LHGDN |
Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner.
|
12842888 |
2003 |
|
Seizures
|
0.020 |
GeneticVariation
|
phenotype |
BEFREE |
Importantly, in utero electroporation of the RHEB p.Y35L variant in mice induced S6 phosphorylation, cytomegalic neurons, dysregulated neuron migration, abnormal electroencephalogram, and seizures, all of which are found in patients with FCDII.
|
31337748 |
2019 |
|
Liver carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Integrated analysis of circRNA-100338, miR-141-3p, and target genes revealed that RHEB, a key regulator in mTOR signaling pathway, was the target of miR-141-3p in hepatitis B-related HCC.
|
31157168 |
2019 |
|
Liver carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
<i>In vivo</i>, upon downregulation of RHEB expression, the tumorigenic ability of HCC significantly decreased (P<0.05).
|
29467900 |
2018 |
|
Seizures
|
0.020 |
GeneticVariation
|
phenotype |
BEFREE |
Functional testing of mutant RHEB in vertebrate animal models indicates pathway hyperactivation with a concomitant increase in cell and head size, aberrant neuronal migration, and induction of seizures, concordant with the human phenotype.
|
29051493 |
2017 |
|
Amaurosis congenita of Leber, type 1
|
0.010 |
Biomarker
|
disease |
BEFREE |
Additionally, rapamycin (a mTOR antagonist) notably attenuated the effects of Rheb on the autophagy, proliferation, apoptosis, and MITF expression in LCA-treated melanoma cells.
|
31793097 |
2020 |
|
Autoimmune Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Mice bearing RagA-RagB- or Rheb1-Rheb2-deficient Treg cells developed a fatal autoimmune disease and had reduced eTreg cell accumulation and function.
|
31668641 |
2019 |
|
Hepatitis B
|
0.010 |
Biomarker
|
disease |
BEFREE |
Integrated analysis of circRNA-100338, miR-141-3p, and target genes revealed that RHEB, a key regulator in mTOR signaling pathway, was the target of miR-141-3p in hepatitis B-related HCC.
|
31157168 |
2019 |
|
Degenerative polyarthritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Human and mouse OA cartilage is degenerated and has markedly reduced levels of RHEB.
|
31229684 |
2019 |
|
Adrenoleukodystrophy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Alcohol-related decrease in mechanistic target of rapamycin (mTOR) and Ras homolog enriched in brain (Rheb), that initiate autophagy, correlated with increased Beclin1 and autophagy-related protein 7 (Atg7), proteins involved in phagophore-autophagosome formation, in ALD.
|
31090940 |
2019 |
|
Lesion of brain
|
0.010 |
GeneticVariation
|
group |
BEFREE |
This RHEB mutation carrier had a dramatic increase of ribosomal protein S6 phosphorylation, indicating mTOR activation in the region of the brain lesion.
|
31337748 |
2019 |