|
Hereditary Prostate Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The interferon antiviral pathways and prostate cancer genetics converge on a regulated endoribonuclease, RNase L. Positional cloning and linkage studies mapped Hereditary Prostate Cancer 1 (<i>HPC1</i>) to <i>RNASEL</i>.
|
28257035 |
2017 |
|
Hereditary Prostate Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Many polymorphisms in genes, such as ELAC2 (locus HPC2), RNase L (locus hereditary prostate cancer 1 gene [HPC1]), and MSR1 have been recognized as important genetic factors that confer an increased risk of developing prostate cancer in many populations.
|
23141781 |
2013 |
|
Hereditary Prostate Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A role in tumor suppression was inferred by mapping of the RNase L gene to the hereditary prostate cancer 1 (HPC1) gene, which in turn led to discovery of the xenotropic murine leukemia-related virus.
|
21190483 |
2011 |
|
Hereditary Prostate Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The search for viral causes of these syndromes was reignited by the finding that RNase L activity was low in hereditary prostate cancer and some CFS patients.
|
20425007 |
2010 |
|
Hereditary Prostate Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recently, RNase L was identified as the hereditary prostate cancer 1 gene.
|
17681844 |
2008 |
|
Hereditary Prostate Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The RNASEL and HPC2/ELAC2 genes have been implicated in hereditary prostate cancer.
|
18767027 |
2008 |
|
Hereditary Prostate Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The RNASEL gene at 1q25 has been identified as a hereditary prostate cancer susceptibility gene, but to date, no study has investigated the role of RNASEL variants in Hispanic Caucasian men with prostate cancer.
|
17908993 |
2007 |
|
Hereditary Prostate Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
ELAC2, MSR1, and RNASEL are candidate genes for hereditary prostate carcinoma (HPC).
|
16114055 |
2006 |
|
Hereditary Prostate Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
RNASEL is thought to be a susceptibility gene for hereditary prostate cancer and encodes the endoribonuclease RNase L, which has a role in apoptosis and is a candidate tumour-suppressor protein.
|
16054567 |
2005 |
|
Hereditary Prostate Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, the RNase L gene, RNASEL, was mapped to the hereditary prostate cancer 1 (HPC1) gene.
|
16241858 |
2005 |
|
Hereditary Prostate Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The hereditary prostate cancer 1 (HPC1) allele maps to the RNASEL gene encoding a protein (RNase L) implicated in the antiviral activity of interferons.
|
15604285 |
2004 |
|
Hereditary Prostate Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The RNASEL gene, a strong candidate for the hereditary prostate cancer 1 allele (HPC1), encodes a single-stranded specific endoribonuclease involved in the antiviral actions of IFNs.
|
14583476 |
2003 |
|
Hereditary Prostate Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Genetics studies from several laboratories in the U.S., Finland, and Israel, support the recent identification of the RNase L gene, RNASEL, as a strong candidate for the long sought after hereditary prostate cancer 1 (HPC1) allele.
|
12590567 |
2003 |
|
Hereditary Prostate Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The ribonuclease L (RNase L) gene has been reported as the putative hereditary prostate cancer gene located at HPC1.
|
15040862 |
2003 |
|
Hereditary Prostate Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The RNASEL gene maps to the hereditary-prostate-cancer (HPC)-predisposition locus at 1q24-q25 (HPC1) and was recently shown to harbor truncating mutations in two families with linkage to HPC1.
|
11941539 |
2002 |
|
Hereditary Prostate Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that polymorphic changes within the RNASEL gene may be associated with increased risk of familial but not sporadic PC.
|
12022038 |
2002 |
|
Hereditary Prostate Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Here we report that germline mutations in the gene encoding 2'-5'-oligoadenylate(2-5A)-dependent RNase L (RNASEL) segregate in prostate cancer families that show linkage to the HPC1 (hereditary prostate cancer 1) region at 1q24-25 (ref.9).
|
11799394 |
2002 |
|
Hereditary Prostate Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
HPC1/RNASEL was recently identified as a candidate gene for hereditary prostate cancer.
|
12145743 |
2002 |
|
Hereditary Prostate Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
RNASEL (encoding ribonuclease L) has recently been proposed as a candidate for the hereditary prostate cancer (HPC1) gene.
|
12415269 |
2002 |