RNF2, ring finger protein 2, 6045

N. diseases: 63; N. variants: 1
Disease: melanoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0025202
Disease: melanoma
melanoma 		0.030 AlteredExpression disease BEFREE Our data indicate that development of melanoma is associated with significant changes in RNF2 intratumoral expression and imply that at least for some patients the enhancement of the expression levels of RNF2 in both primary and metastatic lesions may be considered a favorable prognostic factor in melanoma. 29707138 2018
CUI: C0025202
Disease: melanoma
melanoma 		0.030 GeneticVariation disease BEFREE Germline mutations in BAP-1 are associated with a cancer syndrome that involves uveal and cutaneous melanoma, malignant mesothelioma, atypical Spitz tumors, and clear-cell renal cell carcinoma. 29981911 2018
CUI: C0025202
Disease: melanoma
melanoma 		0.030 Biomarker disease BEFREE In summary, RNF2 regulates distinct biologic processes in the genesis and progression of melanoma via different molecular mechanisms. 26450788 2015