GAS5, growth arrest specific 5, 60674

N. diseases: 184; N. variants: 5
Disease: Prostate carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.070 GeneticVariation disease BEFREE This is the first study to report the correlation between GAS5 gene polymorphism and prostate cancer prognosis. 31673232 2019
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.070 Biomarker disease BEFREE And the signaling pathways underlying the function of GAS5 during the pathogenesis of prostate cancer (PC) were clarified. 30317620 2019
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.070 Biomarker disease BEFREE Long non-coding RNA (lncRNA) GAS5 has been identified to mediate cell proliferation in prostate cancer, although its role in CNP is still unclear. 30892130 2019
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.070 Biomarker disease BEFREE Therefore, miR-145 may inhibit cell proliferation and induce apoptosis in human prostate carcinoma by upregulating lncRNA GAS5. 31423164 2019
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.070 Biomarker disease BEFREE Collectively, these findings determine that GAS5 functions as a tumor suppressor in prostate cancer development and progression via targeting P27<sup>Kip1</sup><b>Implications:</b> This study reveals a molecular pathway involving lncRNA GAS5/E2F1/P27<sup>Kip1</sup> which regulates cell proliferation and could be a potential therapeutic target in prostate cancer.<i></i>. 28396462 2017
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.070 Biomarker disease BEFREE We also constructed a GAS5-miRNA network to explain the different roles of different GAS5 transcripts in PCa. 28771526 2017
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.070 AlteredExpression disease BEFREE The effects of mTOR inhibitors on GAS5 lncRNA levels and cell growth were determined in a range of prostate cancer cell lines. 25650269 2015