ROBO2, roundabout guidance receptor 2, 6092

N. diseases: 49; N. variants: 12
Disease: Vesicoureteral Reflux 1 ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C4551858
Disease: Vesicoureteral Reflux 1
Vesicoureteral Reflux 1 		0.060 GeneticVariation disease BEFREE Sequence variations of the ROBO2 gene were investigated in children with nonsyndromic VUR or VUR-RHD. 27002985 2016
CUI: C4551858
Disease: Vesicoureteral Reflux 1
Vesicoureteral Reflux 1 		0.060 GeneticVariation disease BEFREE Non-synonymous variants in ROBO2 have been found in a small proportion of patients with primary vesicoureteric reflux (VUR) in various countries. 23536131 2013
CUI: C4551858
Disease: Vesicoureteral Reflux 1
Vesicoureteral Reflux 1 		0.060 Biomarker disease BEFREE Common genetic variants in four genes (GREM1, EYA1, ROBO2 and UPK3A) show a trend towards association with the development of primary VUR (GREM1, EYA1, ROBO2) or duplex collecting system (EYA1 and UPK3A). 22558067 2012
CUI: C4551858
Disease: Vesicoureteral Reflux 1
Vesicoureteral Reflux 1 		0.060 GeneticVariation disease BEFREE We conclude that gene variants in ROBO2 and SLIT2 are rare causes of VUR in humans. 19350278 2009
CUI: C4551858
Disease: Vesicoureteral Reflux 1
Vesicoureteral Reflux 1 		0.060 GeneticVariation disease BEFREE In addition, we identified two novel ROBO2 intracellular missense variants that segregate with CAKUT and VUR in two unrelated families. 17357069 2007
CUI: C4551858
Disease: Vesicoureteral Reflux 1
Vesicoureteral Reflux 1 		0.060 GeneticVariation disease BEFREE Previous studies in humans have also suggested loci on chromosomes 6p21, 10q26, and 19q13, whereas mutations in ROBO2 were recently reported in some patients with VUR. 15829711 2005