It may be concluded that ROCK1 contributes to the invasion and migration of neuroblastoma cells by directly downregulating miR-506; thus, leading to the upregulation of ROCK1, which promotes cell invasion and migration.
Pharmacological or genetic inhibition of ROCK1 and 2, key molecules in Rho signaling, resulted in neuroblastoma cell differentiation and inhibition of neuroblastoma cell growth, migration, and invasion.
Specifically, inhibition of ROCK1 and MAPK1 reduces phosphorylation levels of the motor protein myosin light chain (MLC) leading to a significant inhibition of the invasive and migratory potential of neuroblastoma cells.