DisGeNET - a database of gene-disease associations

ROCK1, Rho associated coiled-coil containing protein kinase 1, 6093

N. diseases: 157; N. variants: 13

Disease: Mammary Neoplasms ×

Source: ALL

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Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _g

DPI _g

pLI

EI _gda

EL _gda

Score _gda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Disease

Score _gda

Association Type

Type

Original DB

Sentence supporting the association

PMID

PMID Year

CUI:	C1458155
Disease:	Mammary Neoplasms

Mammary Neoplasms

0.120

GeneticVariation

group

CLINVAR

Activating ROCK1 somatic mutations in human cancer.

20140017

2010

CUI:	C1458155
Disease:	Mammary Neoplasms

Mammary Neoplasms

0.120

Biomarker

group

LHGDN

The expression and prognostic value of ROCK I and ROCK II and their role in human breast cancer.

18695890

2008

CUI:	C1458155
Disease:	Mammary Neoplasms

Mammary Neoplasms

0.120

Biomarker

group

LHGDN

Protein kinase A gating of a pseudopodial-located RhoA/ROCK/p38/NHE1 signal module regulates invasion in breast cancer cell lines.

15843433

2005