Adenocarcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The aim of this study was to evaluate the adequacy of EBUS-TBNA in providing adequate size specimens for EGFR, ALK and ROS1 genetic mutation analysis in patients with adenocarcinoma or not otherwise specified (NOS) lung cancer.
|
30582673 |
2019 |
Adenocarcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Subsequently, mutations in EGFR and BRAF, rearrangements in ALK and ROS1 were evaluated in 69 resected pN1-2M0 adenocarcinoma cases.
|
31317326 |
2019 |
Adenocarcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
ROS1 gene rearrangements exist in 1-2% of non-small cell lung cancers, typically occurring in younger, never or light smokers with adenocarcinoma.
|
31313100 |
2019 |
Adenocarcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Although the MET gene amplification and ROS1 gene fusion in NSCL adenocarcinoma were low-probability events, detection of the gene status of EGFR, ROS1, and MET will facilitate screening more NSCL adenocarcinoma patients who might benefit from targeted therapy.
|
28952227 |
2019 |
Adenocarcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
HER2 mutations were detected in 29 of 572(5.1%) specimens from a selected population of EGFR/KRAS/BRAF/ALK/ROS1 negative patients.All of them are adenocarcinomas.
|
29587667 |
2018 |
Adenocarcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
ROS1 rearrangement is most often identified in never-smokers with adenocarcinoma and EGFR and ALK receptor tyrosine kinase gene (ALK) wild type.
|
29883837 |
2018 |
Adenocarcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
It is widely known that ROS1 rearrangement mostly occurs in the adenocarcinoma subtype of non-small-cell lung cancer.
|
30083883 |
2018 |
Adenocarcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Key new recommendations include ROS1 testing for all adenocarcinoma patients; the inclusion of additional genes (ERBB2, MET, BRAF, KRAS, and RET) for laboratories that perform next-generation sequencing panels; immunohistochemistry as an alternative to fluorescence in situ hybridization for ALK and/or ROS1 testing; use of 5% sensitivity assays for EGFR T790M mutations in patients with secondary resistance to EGFR inhibitors; and the use of cell-free DNA to "rule in" targetable mutations when tissue is limited or hard to obtain.
|
29396253 |
2018 |
Adenocarcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
In conclusion, the specific histology of adenocarcinoma on cytological materials should promote testing for ROS1 immunohistochemistry.
|
29076659 |
2018 |
Adenocarcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
In the subgroup analysis, which was based on tumor subtype, the rate of ROS1 rearrangement and IHC positivity was 2.9% (95% CI 1.9, 4.5) and 0.6% (95% CI 0.3, 1.2) in adenocarcinoma and non-adenocarcinoma, respectively.
|
29874982 |
2018 |
Adenocarcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Key new recommendations include ROS1 testing for all adenocarcinoma patients; the inclusion of additional genes (ERBB2, MET, BRAF, KRAS, and RET) for laboratories that perform next-generation sequencing panels; immunohistochemistry as an alternative to fluorescence in situ hybridization for ALK and/or ROS1 testing; use of 5% sensitivity assays for EGFR T790M mutations in patients with secondary resistance to EGFR inhibitors; and the use of cell-free DNA to "rule in" targetable mutations when tissue is limited or hard to obtain.
|
29398453 |
2018 |
Adenocarcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Key new recommendations include ROS1 testing for all adenocarcinoma patients; the inclusion of additional genes ( ERBB2, MET, BRAF, KRAS, and RET) for laboratories that perform next-generation sequencing panels; immunohistochemistry as an alternative to fluorescence in situ hybridization for ALK and/or ROS1 testing; use of 5% sensitivity assays for EGFR T790M mutations in patients with secondary resistance to EGFR inhibitors; and the use of cell-free DNA to "rule in" targetable mutations when tissue is limited or hard to obtain.
|
29355391 |
2018 |
Adenocarcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
This review summarizes the hot topics of immunohistochemistry in lung cancer, including (i) adenocarcinoma vs squamous cell carcinoma; (ii) neuroendocrine markers; (iii) ALK, ROS1, and EGFR; (iv) PD-L1 (CD274); (v) lung carcinoma vs malignant mesothelioma; and (vi) NUT carcinoma.
|
29538329 |
2018 |
Adenocarcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The rearrangements of ALK/ROS1 are correlated with age, smoking status, expressions of TTF1 & napsin A and solid predominant adenocarcinoma subtype.
|
29268402 |
2017 |
Adenocarcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Interestingly, the overall survival of the 13 ROS1-positive patients with lung cancer from initiation of pemetrexed-based chemotherapy was significantly prolonged when compared with that of 169 pemetrexed-treated patients with EGFR/anaplastic lymphoma kinase/ROS1-negative adenocarcinoma (p = 0.01).
|
27575422 |
2017 |
Adenocarcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Patient harboring a novel PIK3CA point mutation after acquired resistance to crizotinib in an adenocarcinoma with ROS1 rearrangement: A case report and literature review.
|
28845578 |
2017 |
Adenocarcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Three biomarker-specified groups of advanced lung adenocarcinomas can now be defined, each paired with a specific palliative first-line systemic therapy of proven clinical benefit: (1) EGFR/ALK/ROS1-affected adenocarcinoma paired with a matched tyrosine kinase inhibitor (∼20% of cases), (2) PD-L1-enriched adenocarcinoma (TPS ≥50%) paired with anti-PD-1 pembrolizumab (∼30% of cases), and (3) biomarker-negative (i.e., EGFR/ALK/ROS1/PD-L1-negative) adenocarcinoma paired with platinum doublet chemotherapy with or without bevacizumab (∼50% of cases).
|
28104537 |
2017 |
Adenocarcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Four out of five ROS1 rearranged patients were female, never smokers and with adenocarcinoma histology.
|
26783962 |
2016 |
Adenocarcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Patients harboring ROS1 rearrangement were mostly young (8/10), females (7/10) and non-smokers (7/10) with adenocarcinoma (10/10) and acinar pattern.
|
27488371 |
2016 |
Adenocarcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
19 tumors were identified with ROS1 rearrangement (3.7% of adenocarcinomas).
|
27708233 |
2016 |
Adenocarcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Patients with ROS1 gene rearrangements were younger and typically never-smokers, with the tumors all being adenocarcinomas with higher-grade architectural features and focal signet ring morphologic features (two of five).
|
27179848 |
2016 |
Adenocarcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Synchronous lung cancers from 60 patients (42 with adenocarcinoma and 18 with squamous cell carcinoma), clinically considered to represent intrapulmonary metastases, were histologically subtyped according to the 2015 World Health Organization classification of lung tumors and subjected to genotypic analysis (KRAS, EGFR, BRAF, PIK3CA, ALK, MET and ROS1 in adenocarcinoma and PIK3CA and p16 in squamous cell carcinoma).
|
27080983 |
2016 |
Adenocarcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Our findings provide evidence that ALK or ROS1 translocations are crucial events in tumourigenesis of pulmonary adenocarcinoma of very young patients, including pediatric patients.
|
27237034 |
2016 |
Adenocarcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
ROS1-rearranged adenocarcinoma exhibited distinct morphological and clinicopathological features.
|
26149475 |
2015 |
Adenocarcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
ROS1 rearrangement was detected in 3 of 375 samples (0.8 %); all of whom were female, never-smokers, and harbored an adenocarcinoma component.
|
25374304 |
2015 |