|
Heart failure
|
0.300 |
Biomarker
|
disease |
BEFREE |
Our data revealed that CTCF protects cardiomyocytes from ER stress through S100A1-RYR2 axis, and can be applied as a therapeutic target for the treatment of pediatric heart failure in future.
|
31837328 |
2020 |
|
Heart failure
|
0.300 |
Biomarker
|
disease |
BEFREE |
Moreover, the over-activated calcium handling related protein CaMKII and RyR2 in heart failure was reversed by resiniferatoxin administration.
|
31811858 |
2020 |
|
Heart failure
|
0.300 |
Biomarker
|
disease |
BEFREE |
Ryanodine receptor 2 (RyR2) plays an important role in maintaining the normal heart function, and mutantions can lead to arrhythmia, heart failure and other heart diseases.
|
31143551 |
2019 |
|
Heart failure
|
0.300 |
Biomarker
|
disease |
BEFREE |
PKA-dependent "hyperphosphorylation" of the RyR2 channel has been proposed as a major impairment that contributes to progression of heart failure.
|
30541771 |
2019 |
|
Heart failure
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Rather, CaM's biological action on human RyR2 appears to be more nuanced, with inhibitory activity only on phosphorylated RyR2 channels, which occurs during exercise or in patients with heart failure.
|
30928430 |
2019 |
|
Heart failure
|
0.300 |
Biomarker
|
disease |
BEFREE |
Our results provide preclinical experimental evidence that the cardiac expression of RyR2 nanobodies with AAV9 vectors is a promising therapeutic strategy for HF.-Li, T., Shen, Y., Lin, F., Fu, W., Liu, S., Wang, C., Liang, J., Fan, X., Ye, X., Tang, Y., Ding, M., Yang, Y., Lei, C., Hu, S. Targeting RyR2 with a phosphorylation site-specific nanobody reverses dysfunction of failing cardiomyocytes in rats.
|
30885011 |
2019 |
|
Heart failure
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Indeed, we identified an L2483R mutation in the ryanodine receptor type 2 (RyR2) in a 2-month-old male patient with VSD with HF.
|
30308486 |
2018 |
|
Heart failure
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Development of HF was not aggravated by increased SR Ca<sup>2+</sup> leak due to RyR2 mutation (R2474S) in volume overload, an SR Ca<sup>2+</sup> leak-independent HF model.
|
30209242 |
2018 |
|
Heart failure
|
0.300 |
Biomarker
|
disease |
BEFREE |
Calmodulin (CaM) dissociation from RyR2 has been associated with diastolic Ca<sup>2+</sup> leak in heart failure.
|
29248564 |
2018 |
|
Heart failure
|
0.300 |
Biomarker
|
disease |
BEFREE |
Since HF is commonly associated with oxidative stress, we studied whether oxidation of ryanodine receptor (RyR2) contributes to this defect.
|
29500669 |
2018 |
|
Heart failure
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Several studies have linked increased SR Ca leak during myocardial infarction and heart failure to the activation of RyR2 in response to oxidative stress.
|
30574097 |
2018 |
|
Heart failure
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In this study, we investigated the potential of adeno-associated virus (AAV)-9-mediated cardiac expression of a Type-2 ryanodine receptor (RyR2) degradation-associated gene, Presenilin 1 (PSEN1), to combat post-ischaemic heart failure.
|
29521549 |
2018 |
|
Heart failure
|
0.300 |
Biomarker
|
disease |
BEFREE |
In a canine heart failure (HF) model, OS generation and oxidized-CaMKII-induced (Ox-CaMKII-induced) RyR2 and Nav1.5 signaling were increased preferentially in the PLA (compared with left atrial appendage).
|
30385719 |
2018 |
|
Heart failure
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Cardiac adrenergic response and progression towards HF proceed unaltered in mice harboring the RyR2-S2808A mutation.
|
28065668 |
2017 |
|
Heart failure
|
0.300 |
Biomarker
|
disease |
BEFREE |
In heart failure (HF), dysregulated cardiac ryanodine receptors (RyR2) contribute to the generation of diastolic Ca<sup>2+</sup> waves (DCWs), thereby predisposing adrenergically stressed failing hearts to life-threatening arrhythmias.
|
28612155 |
2017 |
|
Heart failure
|
0.300 |
Biomarker
|
disease |
BEFREE |
Overactivity of Ca<sup>2+</sup>/calmodulin-dependent protein kinase II (CaMKII) with hyperphosphorylation of ryanodine receptors (RyR2) at the CaMKII-site is recognized to be central for heart failure and arrhythmias.
|
28451724 |
2017 |
|
Heart failure
|
0.300 |
Biomarker
|
disease |
BEFREE |
Correction of impaired calmodulin binding to RyR2 as a novel therapy for lethal arrhythmia in the pressure-overloaded heart failure.
|
27771553 |
2017 |
|
Heart failure
|
0.300 |
Biomarker
|
disease |
BEFREE |
That RyR2 is remodelled and its function disturbed in heart failure is well recognized, but poorly understood.
|
28131631 |
2017 |
|
Heart failure
|
0.300 |
Biomarker
|
disease |
BEFREE |
In addition, the role of reduced CaM binding to RyR2 that results from RyR2 phosphorylation or from oxidation of either RyR2 or CaM contributes to the progression of heart failure is reviewed.
|
27626620 |
2017 |
|
Heart failure
|
0.300 |
Biomarker
|
disease |
BEFREE |
The current amplitude of the MG23 full-open state was consistent with that previously reported for RyR2 sub-conductance gating, suggesting that in heart failure in which Zn<sup>2+</sup> levels are elevated, RyR2 channels do not gate in a sub-conductance state, but rather MG23-gating becomes more apparent.
|
28630041 |
2017 |
|
Heart failure
|
0.300 |
Biomarker
|
disease |
BEFREE |
Changes in expression levels of these phosphatases, their activity and targeting to the RyR2 macromolecular complex were demonstrated in many animal models of cardiac disease and humans and are implicated in cardiac arrhythmia and heart failure.
|
27585747 |
2016 |
|
Heart failure
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
We investigated whether the RyR2 rs3766871 variant is associated with aborted sudden cardiac death or ICD therapy for ventricular tachycardia (VT)/fibrillation (VF) in heart failure (HF) patients implanted with a cardioverter defibrillator (ICD).
|
25773045 |
2015 |
|
Heart failure
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Recent studies suggest that variants in two calcium handling genes (RyR2 and CASQ2) associated with sudden cardiac death (SCD) and non-sudden cardiac death (NSCD) in subjects with heart failure and coronary artery disease, respectively.
|
26196381 |
2015 |
|
Heart failure
|
0.300 |
Biomarker
|
disease |
BEFREE |
Defective CaM-RyR2 interaction is associated with heart failure.
|
25036739 |
2014 |
|
Heart failure
|
0.300 |
Biomarker
|
disease |
BEFREE |
RyR2 channels are oxidized, nitrosylated, and hyperphosphorylated by protein kinase A (PKA) in heart failure, resulting in "leaky" channels.
|
23507255 |
2013 |