RYR2, ryanodine receptor 2, 6262

N. diseases: 160; N. variants: 116
Disease: precancerous lesions ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0940937
Disease: precancerous lesions
precancerous lesions 		0.010 AlteredExpression phenotype BEFREE Immunohistochemical staining of tissue sections unraveled a gradual loss of RYR2 expression from normal mucosa via dysplastic lesion to invasive cancer and indicated that reduced RYR2 expression in adjacent tissue and precancerous lesions might serve as risk factor for unfavorable prognosis and upcoming malignant conversion. 31135957 2019