Major Depressive Disorder
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
Our study suggests that low BDNF levels may play a pivotal role in the pathophysiology of MDD and that antidepressants may increase BDNF in depressed patients.
|
12842310 |
2003 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This finding suggests the BDNF polymorphism investigated plays no major role in the pathogenesis of MDD.
|
14582140 |
2003 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our previous studies show that the brain-derived neurotrophic factor (BDNF) may play a role in the pathophysiology of major depressive disorders and eating disorders.
|
15913870 |
2005 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our findings suggest that BDNF may be a susceptibility gene for MDD and schizophrenia-in particular, in a subgroup of patients with schizophrenia with a lifetime history of depressive symptoms.
|
16005437 |
2005 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Newer hypotheses of depression neurobiology suggest closer study of genes related to neurotoxic and neuroprotective (neurotrophic) processes and to overactivation of the hypothalamic-pituitary axis, with mixed evidence regarding association of MDD with polymorphisms in one such gene (brain-derived neurotrophic factor [BDNF]).
|
16300747 |
2006 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Brain-derived neurotrophic factor gene polymorphism (Val66Met) and citalopram response in major depressive disorder.
|
16979146 |
2006 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We genotyped the BDNF-gene Val66Met polymorphism in 110 elderly inpatients diagnosed with major depression and 171 age- and sex-similar control subjects.
|
16343697 |
2006 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Several studies have linked 5-HT1A C1019G and BDNF G196A (Val66Met) gene polymorphisms to major depressive disorder (MDD) and the actions of antidepressants.
|
17401528 |
2007 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To examine the effect of the BDNF Val66Met polymorphism on hippocampal and amygdala volumes in patients with major depression and in healthy control subjects.
|
17404118 |
2007 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our findings support the association of BDNF single nucleotide polymorphism rs6265 and depression, suggesting that this polymorphism may increase susceptibility to major depression in Mexican-Americans.
|
17632285 |
2007 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that the BDNF Val66Met polymorphism is not related to the development of MDD but related to clinical features of MDD in a Japanese population.
|
17510948 |
2007 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Brain-derived neurotrophic factor (BDNF) polymorphisms G196A and C270T are not associated with response to electroconvulsive therapy in major depressive disorder.
|
17036259 |
2007 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
The neurotrophin hypothesis of depression and antidepressant drug action postulates that reduced activity of neurotrophic factors, particularly brain-derived neurotrophic factor (BDNF), plays an important role in the pathogenesis of major depression, and that its restoration may represent a critical mechanism underlying antidepressant therapeutic effect.
|
18781861 |
2008 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
The p75 neurotrophin receptor (p75(NTR)) is an essential component of neurotrophin system, and has been implicated in the pathogenesis of major depressive disorder (MDD) and in the mechanism of antidepressant action.
|
18081157 |
2008 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A functional polymorphism of the brain-derived neurotrophic factor, BDNF Val66Met, is associated with risk for major depression alongside impairments in memory and selective attention.
|
18721847 |
2008 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Recent data suggest that brain-derived neurotrophic factor (BDNF) and the serotonergic system are involved and interact in major depressive disorder and suicidal behavior (SB).
|
18657242 |
2008 |
Major Depressive Disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Gender-related urocortin 1 and brain-derived neurotrophic factor expression in the adult human midbrain of suicide victims with major depression.
|
18329817 |
2008 |
Major Depressive Disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
A systematic review and meta-analysis of clinical studies on major depression and BDNF levels: implications for the role of neuroplasticity in depression.
|
18752720 |
2008 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
The gene encoding brain-derived neurotrophic factor (BDNF) has been suggested as a candidate for major depression, and for depression susceptibility in different neurological and psychiatric diseases.
|
18179845 |
2009 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
No association of the Val66Met polymorphism of the brain-derived neurotrophic factor with hippocampal volume in major depression.
|
19668114 |
2009 |
Major Depressive Disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Brains from persons with major depressive disorder reveal decreased expression for genes in glutamate transport and metabolism, neurotrophic signaling (eg, FGF, BDNF and VGF), and MAP kinase pathways.
|
18923405 |
2009 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Identification of novel genetic polymorphisms in the BDNF gene and assessment of their frequencies and associations with MDD or antidepressant response.
|
19414708 |
2009 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We conclude that SNPs rs6265, rs10835210 and rs2030324 of the BDNF gene are unlikely to play a critical role in the pathogenesis of MDD.
|
19699537 |
2009 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
In MDD, reductions in (pro)BDNF were seen in all layers of the right but not the left hippocampus with no changes in the dentate gyrus.
|
19376528 |
2009 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
While BDNF was not associated with major depression as a categorical diagnosis, the BDNF rs7124442 TT genotype was significantly related to worse treatment outcome over 6 wk in major depression (p = 0.01) particularly in anxious depression (p = 0.003) in the German sample.
|
19236730 |
2010 |