BDNF, brain derived neurotrophic factor, 627

N. diseases: 992; N. variants: 56
Disease: Major Depressive Disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.400 Biomarker disease BEFREE 1) The age-related decrease in BDNF transcripts observed in control subjects corresponds with further age-related decreases in BDNF and BDNF-dependent gene expression in MDD subjects; 2) most MDD-related genes are frequently age-regulated in both MDD and control subjects; 3) the effects of MDD and age are positively correlated; 4) most genes that are age-dependent in control subjects display greater age effects in MDD subjects; and 5) the increased prevalence of age effects in MDD corresponds to similar trends in controls, rather than representing de novo age effects. 23570888 2013
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.400 AlteredExpression disease BEFREE : The results suggest that the existence of major depression in pregnant women may negatively affect fetal circulating BDNF levels. 30905131 2019
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.400 AlteredExpression disease BEFREE Major depressive disorder (MDD) is a highly prevalent illness that affects large populations across the world, and increasing evidence suggests that neuroinflammation and levels of brain-derived neurotrophic factor (BDNF) are closely related to depression. 29058041 2018
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.400 GeneticVariation disease BEFREE Brain-derived neurotrophic factor gene polymorphism (Val66Met) and citalopram response in major depressive disorder. 16979146 2006
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.400 GeneticVariation disease BEFREE Brain-derived neurotrophic factor (BDNF) polymorphisms G196A and C270T are not associated with response to electroconvulsive therapy in major depressive disorder. 17036259 2007
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.400 AlteredExpression disease BEFREE BDNF mRNA expression was significantly decreased in PBMCs of MDD patients, with or without a history of suicide attempts, when compared with healthy controls (Z=-5.233, p<0.001). 20207421 2010
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.400 GeneticVariation disease BEFREE Brain derived neurotrophic factor gene polymorphism (Val66Met) and short-term antidepressant response in major depressive disorder. 20674983 2010
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.400 GeneticVariation disease BEFREE Brain-derived neurotrophic factor gene polymorphisms: influence on treatment response phenotypes of major depressive disorder. 21188787 2011
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.400 Biomarker disease BEFREE Brain-derived neurotrophic factor signaling and subgenual anterior cingulate cortex dysfunction in major depressive disorder. 23128924 2012
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.400 Biomarker disease BEFREE BDNF Met66 modulates the cumulative effect of psychosocial childhood adversities on major depression in adolescents. 24683520 2014
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.400 Biomarker disease BEFREE Brain-derived neurotrophic factor (BDNF) and its receptor, tropomyosin-related kinase B (TrkB), have emerged as key regulators of brain plasticity and represent disease-modifying targets for several brain disorders, including Alzheimer's disease and major depressive disorder. 28831019 2017
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.400 GeneticVariation disease BEFREE BDNF and NRG1 polymorphisms and temperament in selective serotonin reuptake inhibitor-treated patients with major depression. 29310728 2018
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.400 Biomarker disease BEFREE BDNF exon IV and p11 promoter methylation was not associated with test performance.<b>Conclusions:</b> Our results corroborate a concomitant amelioration of executive dysfunctions with successful antidepressant therapy and support a role of BDNF in the neural mechanisms underlying the normalisation of executive dysfunctions in MDD.<b>ClinicalTrials.gov number:</b> NCT00974155; EudraCT: 2008-008280-96. 29334322 2019
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.400 Biomarker disease BEFREE BDNF and miRNA in MDD had been investigated widely in the recent years, but the relationships between miRNAs and antidepressants were less studied. 30269040 2018
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.400 Biomarker disease BEFREE Brain-derived neurotrophic factor (BDNF), an essential factor for maintaining brain functions, has been reported to be reduced in various neurological diseases, including Alzheimer's disease and major depression. 30753865 2019
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.400 Biomarker disease BEFREE Brain-derived neurotrophic factor (BDNF) is a neurotrophin with a well-established role in MDD etiopathology: it is altered in depressed patients as well as in animal models of the disease and its changes are restored by antidepressant drugs. 31379496 2019
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.400 Biomarker disease BEFREE Brain derived neurotrophic factor (BDNF) has been linked to the etiology and pathology of Major Depressive Disorder (MDD). 31449911 2019
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.400 GeneticVariation disease BEFREE A functional polymorphism of the brain-derived neurotrophic factor, BDNF Val66Met, is associated with risk for major depression alongside impairments in memory and selective attention. 18721847 2008
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.400 GeneticVariation disease BEFREE A significant effect of the interaction of the BDNF Val66Met polymorphism and MDD on the fractional anisotropy values of the right uncinate fasciculus was observed. 29414128 2018
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.400 AlteredExpression disease BEFREE A systematic review and meta-analysis of clinical studies on major depression and BDNF levels: implications for the role of neuroplasticity in depression. 18752720 2008
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.400 Biomarker disease BEFREE A total of 26 outpatients with treatment-resistant MDD and 27 matched healthy controls underwent magnetic resonance imaging and genotyping for six SNPs in monoaminergic genes [serotonin transporter (SLC6A4), norepinephrine transporter (SLC6A2), serotonin 1A and 2A receptors (HTR1A and HTR2A), catechol-O-methyltransferase (COMT), and brain-derived neurotrophic factor (BDNF)]. 25990886 2015
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.400 AlteredExpression disease BEFREE Acute and subsequent continuation electroconvulsive therapy elevates serum BDNF levels in patients with major depression. 31000384 2019
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.400 GeneticVariation disease BEFREE Although not observed in younger adult cohorts, in older individuals the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism is associated with major depressive disorder (MDD) risk. 20195291 2011
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.400 Biomarker disease BEFREE Although the role of brain-derived neurotrophic factor (BDNF) in the pathophysiology of MDD remains unclear, its modulation of the efficacy of antidepressants is clearly established. 25568448 2015
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.400 GeneticVariation disease BEFREE Analyses were stratified either by gender or ethnicity (Asian and Caucasian) because MDD is more prevalent in women and in Caucasians and because BDNF allele frequencies differ by ethnicity. 18852698 2010