|
Depressive disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Collectively, our findings demonstrate that VF extract has antidepressant-like activity against CRS-induced depression through its anti-inflammatory and antioxidant effects by inhibiting BDNF expression.
|
31452446 |
2019 |
|
Depressive disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Treatment with STH_KP17001 reversed VCD-induced anxiety and depression through AMP-activated protein kinase (AMPK) activation and brain-derived neurotrophic factor (BDNF) expression in the cerebral cortex, while improving heart hypertrophy through inactivation of inhibitor of kappaB α (IκBα) in the heart.
|
31474708 |
2019 |
|
Depressive disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Our study suggested that heavy metal could be worsen BDNF level which plays its important role on biological effect of maternal depressive disorder and newborn neurodevelopment.
|
31199848 |
2019 |
|
Depressive disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
A logistic regression model investigating age, sex, serum BDNF levels, dietary quality and depression, as well as any interactions, found that lower dietary quality, and surprisingly, higher BDNF levels, were associated with increased depression risk, P = 0.037 and P < 0.001, respectively.
|
29280414 |
2019 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Pain and depressive-like behavior were measured over 14 days and brain-derived neurotrophic factor (BDNF; a factor involved in nociception and depression) and glucocorticoid receptor (GR; a stress-related receptor) expression were measured on day 14.
|
31815911 |
2019 |
|
Depressive disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Dendritic spine remodeling and induction of activity-induced BDNF in the cortex represent important cellular and molecular plasticity mechanisms underlying the efficacy of ECS for treatment of chronic stress-induced depression.
|
29674117 |
2019 |
|
Depressive disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Magnesium and ketamine have a common mechanism of action in the treatment of depression: an increase in GluN2B (NMDAR subunit) expression is related to the administration of both of the agents, as well as inhibition of phosphorylation of eEF2 (eukaryotic elongation factor 2) in cell culture and increase of the expression of BDNF in the hippocampus.
|
31488789 |
2019 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
In addition to ERK, the brain-derived neurotrophic factor (BDNF), an immediate upstream regulator of ERK, the cAMP response element-binding protein (CREB), a transcription factor downstream to ERK, and the MAPK phosphatase (MKP) are equally vulnerable to depression.
|
30737641 |
2019 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
sBDNF was significantly lower in the IG than in the CG (large effect size; Hedge's g = 1.75), while higher insomnia scores, but not depression or anxiety ratings, predicted lower sBDNF levels.
|
30616157 |
2019 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Data of patients with a current depressive and/or anxiety disorder came from the Netherlands Study of Depression and Anxiety, a large, multi-site naturalistic cohort study (n = 1460).Thirty-six biomarkers (e.g. leptin, brain-derived neurotrophic factor, tryptophan) were measured, as well as sociodemographic and clinical characteristics.
|
29860945 |
2019 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
BDNF pro-peptide: physiological mechanisms and implications for depression.
|
31076872 |
2019 |
|
Depressive disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Depression is associated with decreased expression of brain-derived neurotrophic factor (BDNF) which assembled in Golgi apparatus.
|
30734552 |
2019 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Thus, a high dose of vitamin D<sub>3</sub> (5.0 mg/kg sc) could improve the depression-like profile in long-term OVX adult female rats subjected to the CUMS procedure, which might be mediated by the regulation of BDNF and the NT-3/NT-4 signaling pathways in the hippocampus, as well as the corticosterone/ACTH levels of the blood serum.
|
31357443 |
2019 |
|
Depressive disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Decreased level of BDNF is observed in depression and its connection to hypertension has also been demonstrated with affecting the arterial baroreceptors, renin-angiotensin system and endothelial nitric oxide synthase.
|
30767081 |
2019 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
SHC4 regulates BDNF-induced MAPK activation and was previously associated with depression.
|
30149091 |
2019 |
|
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Investigating the potential role of BDNF and PRL genotypes on antidepressant response in depression patients: A prospective inception cohort study in treatment-free patients.
|
31611000 |
2019 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Multiple logistic regression results confirmed the contribution of irisin and BDNF to the occurrence of depression in CHD.
|
31475168 |
2019 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Chronic histamine 3 receptor antagonism alleviates depression like conditions in mice via modulation of brain-derived neurotrophic factor and hypothalamus-pituitary adrenal axis.
|
30458370 |
2019 |
|
Depressive disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The increase in PLC BDNF levels is consistent with previous rat models of depression, and concomitantly, with its suggested role in promoting cocaine-seeking.
|
31062481 |
2019 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
The Role of Dendritic Brain-Derived Neurotrophic Factor Transcripts on Altered Inhibitory Circuitry in Depression.
|
30449530 |
2019 |
|
Depressive disorder
|
0.600 |
PosttranslationalModification
|
disease |
BEFREE |
We asked whether BDNF methylation status is associated with a major adverse cardiac event (MACE), inflammation, and the association with depression comorbidity and its treatment in patients with acute coronary syndrome (ACS).
|
31255678 |
2019 |
|
Depressive disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The aim of this study was to evaluate salivary cortisol and plasma brain-derived neurotrophic factor (BDNF) in people with PD, to compare them with healthy controls and to associate them with levels of anxiety and depression.
|
31265872 |
2019 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Here, we review some of the preclinical and clinical studies aimed at disclosing the role of BDNF and NGF mediated pathophysiological mechanisms of depression and the new therapeutic approaches targeting those key molecules.
|
30235967 |
2019 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Effect of Sertraline, Dosulepin, and Venlafaxine on Non-BDNF Neurotrophins in Patients With Depression: A Cohort Study.
|
30932945 |
2019 |
|
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The results of the present study indicate that BDNF gene polymorphism plays a prominent role in the variation of symptoms among insomnia patients and, further, that this polymorphism is strongly related to the severity of depression.
|
30076879 |
2019 |