|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Together, our novel data indicate that TrkB signaling is a key modulator of AHR and that smooth muscle-derived BDNF mediates these effects during allergic airway inflammation.-Britt, R. D., Jr., Thompson, M. A., Wicher, S. A., Manlove, L. J., Roesler, A., Fang, Y.-H., Roos, C., Smith, L., Miller, J. D., Pabelick, C. M., Prakash, Y. S. Smooth muscle brain-derived neurotrophic factor contributes to airway hyperreactivity in a mouse model of allergic asthma.
|
30351991 |
2019 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The lncRNA GAS5/miR-10a/BDNF regulatory axis played an important role in promoting ASMCs proliferation, thus contributing to asthma.
|
30189218 |
2018 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The Alteration of Irisin-Brain-Derived Neurotrophic Factor Axis Parallels Severity of Distress Disorder in Bronchial Asthma Patients.
|
29217995 |
2017 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this regard, factors such as thymic stromal lymphopoietin (TSLP), an inflammatory cytokine, and brain-derived neurotrophic factor (BDNF), a neurotrophin, have been found critical for nonvascular systems such as airway and asthma.
|
29047096 |
2017 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In this study, we explored the profibrotic influence of BDNF in the context of asthma by examining expression, activity, and deposition of ECM proteins in primary ASM cells isolated from asthmatic vs. nonasthmatic patients.
|
28522569 |
2017 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We genotyped 85,437 individuals aged 20-100 years from the Copenhagen General Population Study for FTO (rs9939609), MC4R (rs17782313), TMEM18 (rs6548238) GNPDA2 (rs10938397) and BDNF (rs10767664); 14,500 individuals experienced wheezing and 5406 had asthma.
|
26504195 |
2016 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Also, BDNF gene distribution exhibited significant differences among those in the healthy group, the group with asthma but no depression, and the group with asthma and depression; however, NPSR1 gene distribution did not vary greatly between the groups.
|
27176146 |
2016 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association between a functional single nucleotide polymorphism in the brain-derived neurotrophic factor gene and risk of child asthma.
|
26662416 |
2015 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Specific BDNF gene polymorphism may contribute to bronchial asthma susceptibility.
|
24863266 |
2015 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Epithelial brushing exon VIb mRNA and total BDNF protein differed among the groups and were higher in subjects with severe asthma than in healthy control subjects (overall P = 0.01, P = 0.02, respectively).
|
25945802 |
2015 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our present meta-analysis suggests that the Val66Met polymorphisms in BDNF gene are potentially associated with asthma risk in Caucasians.
|
26289094 |
2015 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The current review focuses on 1) the importance of BDNF expression and signaling mechanisms in early airway and lung development, critical to both normal neonatal lung function and also its disruption in prematurity and insults such as inflammation and infection; 2) how BDNF, potentially derived from airway nerves modulate neurogenic control of airway tone, a key aspect of airway reflexes as well as dysfunctional responses to allergic inflammation; 3) the emerging idea that local BDNF production by resident airway cells such as epithelium and airway smooth muscle can contribute to normal airway structure and function, and to airway hyperreactivity and remodeling in diseases such as asthma.
|
24560686 |
2014 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Of particular interest, BDNF has been previously implicated in both psychiatric disorders and asthma.
|
25335167 |
2014 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These findings point to a role for BDNF polymorphisms in Chinese Han children with asthma and may inform future genetic or biological studies on childhood asthma.
|
23461616 |
2013 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We genotyped 27 polymorphisms located in neurotrophin genes, using TaqMan SNP genotyping assays or Polymerase Chain Reaction - Restriction Fragments Lengths Polymorphism (PCR-RFLP) in 200 children diagnosed with asthma and 226 controls.
|
22468730 |
2012 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study therefore aims to clarify the relationship between single nucleotide polymorphisms (SNPs) in BDNF and a genetic predisposition to AR and asthma in an ethnic Chinese population of Singapore.
|
21723144 |
2011 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The neurotrophin brain-derived neurotrophic factor (BDNF) has recently been identified as a mediator of airway hyper-responsiveness in asthma.
|
19237390 |
2009 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that genetic variation in the BDNF gene does not contribute significantly to asthma susceptibility or severity.
|
19295238 |
2009 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We systematically investigated whether polymorphisms in the BDNF gene influence the development or severity of asthma and atopic diseases.
|
19895626 |
2009 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
LHGDN |
The aim of this study was to analyze the possible relationship between these two polymorphisms in the BDNF gene and asthma.
|
17584309 |
2007 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to analyze the possible relationship between these two polymorphisms in the BDNF gene and asthma.
|
17584309 |
2007 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Activated macrophages have been shown to produce brain-derived neurotrophic factor (BDNF) in diseases such as multiple sclerosis (MS) or allergic bronchial asthma (BA).
|
15710474 |
2005 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
They are a possible source of elevated neurotrophin levels found in allergy and asthma.
|
15544837 |
2005 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
They are a possible source of elevated neurotrophin levels found in allergy and asthma.
|
12752594 |
2003 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
LHGDN |
Our findings suggest that neurotrophin-mediated activation of bronchial eosinophils might play a role in the regulation of eosinophilic inflammation in allergic asthma.
|
12900521 |
2003 |