|
Gastritis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Studies from the West have indicated that the cagA gene and the associated EPIYA genotype of H. pylori is closely linked to the development of severe gastritis and gastric carcinoma; however, as yet no consistent correlation has been found among the bacteria from East Asia.
|
26934189 |
2016 |
|
Gastritis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the frequency of cagA gene among H. pylori strains is elevated in Iran and it seems to be more frequently associated with gastritis.
|
26230117 |
2015 |
|
Gastritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The cagA gene was identified in 52.1% and 76.2% of isolates from patients with dyspepsia (gastritis and peptic ulcer), respectively.The plasticity region ORFs i.e.
|
24688521 |
2013 |
|
Gastritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Histology revealed the presence of infection in 68% of cases of mild/chronic nonspecific gastritis with others belonging to the GU sequel. cagA gene carriage was observed in 104 (51%) cases or mostly from DU, GU and GC groups, of which 97 were Western type strains while 3 were East-Asian type strains that are rarely observed in South Asia. vacA allelic variant s1am1 was most commonly observed, followed by s1am2, and s1bm1, with direct correlation in diseased cases (gastritis, GU, DU and GC).
|
23493000 |
2013 |
|
Gastritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The study confirms the alarming levels of antibiotic resistance associated with the degree of gastric inflammation and cagA gene carriage in H. pylori strains.
|
22611319 |
2012 |
|
Gastritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Infection with H. pylori possessing the East Asian cagA gene contributes to the progression of gastritis.
|
21736532 |
2011 |
|
Gastritis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We evaluated the presence of the homA, homB, and cagA genes in 286 strains isolated from patients in the U.S. and Colombian populations (126 with gastritis, 96 with duodenal ulcer, and 64 with gastric cancer) by PCR.
|
19710266 |
2009 |
|
Gastritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We studied 144 patients with non-cardia gastric cancer (NCGC)(41/50 with present or past H. pylori infection), 75 with duodenal ulcer (DU)(66 H. pylori infected) and 171 with gastritis (CG)(107 H. pylori infected). cagA gene was present in 24/28 NCGC, 45/59 DU and 56/107 CG.
|
18179773 |
2008 |
|
Gastritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The cagA gene was detectable in 57.1% of gastritis and 92.9% of PUD-associated strains.
|
17434345 |
2007 |
|
Gastritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The gastritis scores of activity and inflammation were associated with the presence of babA2 in antrum specimens but not in corpus specimens. cagA gene encoding in the CagA EPIYA-D region was detected in all samples, and the sequence was completely identical between those from the gastric corpus and antrum.
|
17890898 |
2007 |
|
Gastritis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Although the cagA gene sequence was completely identical between the gastric corpus and the antrum in all patients, the corpus gastritis was more prominent in patients with gastric cancer than those with duodenal ulcer.
|
16543737 |
2006 |
|
Gastritis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
When the patients with different clinical manifestations were compared according to the presence of cagA gene or various vacA genotypes, only the vacA genotypes were significantly different among gastritis, peptic ulcer and gastric cancer patients (chi 2 = 17.8; P = 0.001).
|
16937534 |
2006 |
|
Gastritis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The presence of the cagA gene is strongly associated with atrophic and active gastritis.
|
16724992 |
2006 |
|
Gastritis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Functional oipA genes were correlated with cagA gene; both genes were significantly associated with gastritis activity, peptic ulcer and gastric adenocarcinoma.
|
12161099 |
2002 |
|
Gastritis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Since allelic variation in cagA exists and distinct H. pylori subgenotypes may circulate in different regions, PCR using primers for a variable 3' region of the cagA gene according to a Japanese methodology and for a consensus cagA 3' region used in Western methods was used for cagA detection. cagA was present in 53 (71%) of 75 H. pylori-positive cases when analyzed by the consensus region method and was associated with duodenal ulcer disease (P = 0.02), but not with gastric ulcer (P = 0.26), when compared to patients with duodenitis or gastritis.
|
11158115 |
2001 |
|
Gastritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The cagA gene was detected in 80% of patients with DU and in 52% of those with gastritis (P < 0.0001).
|
10499473 |
1999 |
|
Gastritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The cagA gene was detected in 100% of 16 Helicobacter pylori isolates from patients with gastric carcinoma versus 78% of 18 isolates from patients with duodenal ulcers (P = 0.344) and only 64% of 22 isolates from patients with gastritis only (P = 0.005) in Brazil.
|
9774617 |
1998 |
|
Gastritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Genomic DNA and bacterial mRNA in the gastric mucosa were amplified by polymerase chain reaction (PCR) and reverse transcription PCR, using synthetic oligonucleotide primers to cagA genes to compare the prevalence of cagA genes in 35 patients with non-ulcer gastritis and 99 patients with gastric or duodenal ulcer disease (53 and 46, respectively).
|
9759946 |
1998 |
|
Gastritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The aim of the present study was to correlate molecular evidence of the presence of Helicobacter pylori in gastric biopsy samples, based on analysis of 16S rDNA, vacuolating toxin (vacA), urease A (ureA) and cagA genes, with the clinical, histological and serological findings in patients with H. pylori-associated gastritis.
|
9877190 |
1998 |
|
Gastritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Presence of cagA gene was correlated with active gastritis in 60% of infected children and adults.
|
9376616 |
1997 |
|
Gastritis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The second primer set, which was previously established in a patient population from the Houston area (21 DU patients, 20 from individuals with asymptomatic gastritis) amplified a 1.4-kb region further downstream in the cagA gene.
|
8677987 |
1996 |
|
Gastritis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The high prevalence of the cagA gene in asymptomatic gastritis suggests that it will not prove to be a useful marker to distinguish more virulent or disease-specific H. pylori strains.
|
9398887 |
1996 |
|
Gastritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
All of these observations confirmed the role of this cagA gene as a marker of gastric inflammation in children.
|
8586721 |
1995 |