Immunologic Deficiency Syndromes
|
0.100 |
Biomarker
|
group |
BEFREE |
Human and simian immunodeficiency viruses (HIV and SIV, respectively) initially exploit their accessory Nef protein to increase the responsiveness of infected CD4<sup>+</sup> T cells to stimulation.
|
28261165 |
2017 |
Immunologic Deficiency Syndromes
|
0.100 |
Biomarker
|
group |
BEFREE |
It is well established that the Nef proteins of human and simian immunodeficiency viruses (HIV and SIV) modulate major histocompatibility complex class I (MHC-I) cell surface expression to protect infected cells against lysis by cytotoxic T lymphocytes (CTLs).
|
22013062 |
2012 |
Immunologic Deficiency Syndromes
|
0.100 |
Biomarker
|
group |
BEFREE |
Golgi structure was also investigated in cells in tissue sections of pulmonary vascular lesions in idiopathic PAH (IPAH) and in macaques infected with a chimeric simian immunodeficiency virus containing the human immunodeficiency virus (HIV)-nef gene (SHIV-nef) with subcellular three-dimensional (3D) immunoimaging.
|
21217069 |
2011 |
Immunologic Deficiency Syndromes
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Expression of simian immunodeficiency virus Nef protein in CD4+ T cells leads to a molecular profile of viral persistence and immune evasion.
|
16857233 |
2006 |
Immunologic Deficiency Syndromes
|
0.100 |
Biomarker
|
group |
BEFREE |
However, oral burdens of C. albicans were increased in CD4C/HIV(MutG) Tg mice expressing only the nef gene of HIV-1 and bred on a CD8 gene-deficient background (CD8-/-), compared to control or heterozygous CD8+/- CD4C/HIV(MutG) Tg mice.
|
16552068 |
2006 |
Immunologic Deficiency Syndromes
|
0.100 |
Biomarker
|
group |
BEFREE |
The NEF gene is conserved among members of human and simian immunodeficiency viruses and may play an important role in viral pathogenesis.
|
12824703 |
2004 |
Immunologic Deficiency Syndromes
|
0.100 |
GeneticVariation
|
group |
BEFREE |
When simian immunodeficiency virus (SIV) deleted in the nef gene caused no disease in macaques and provided protection against wild-type SIV challenge, hopes were high that the removal of nef would convert a pathogenic immunodeficiency virus into a live attenuated vaccine.
|
15090885 |
2004 |
Immunologic Deficiency Syndromes
|
0.100 |
Biomarker
|
group |
BEFREE |
Nef proteins from simian immunodeficiency virus-infected chimpanzees interact with p21-activated kinase 2 and modulate cell surface expression of various human receptors.
|
15194762 |
2004 |
Immunologic Deficiency Syndromes
|
0.100 |
Biomarker
|
group |
BEFREE |
Analysis of the open reading frames revealed that the SIVmonNG1 genome codes for a Vpu protein, in addition to Gag, Pol, Vif, Vpr, Tat, Rev, Env, and Nef proteins.
|
12768007 |
2003 |
Immunologic Deficiency Syndromes
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Deletion of the nef gene results in viral attenuation and confers protection against challenge with wild-type simian immunodeficiency virus in macaques.
|
10388660 |
1999 |
Immunologic Deficiency Syndromes
|
0.100 |
GeneticVariation
|
group |
BEFREE |
To understand the virologic basis of these differences, the nef gene from HIV-2-seropositive persons was analyzed because of its importance for disease progression in the genetically related simian immunodeficiency virus (SIV[MAC]).
|
9419171 |
1998 |
Immunologic Deficiency Syndromes
|
0.100 |
Biomarker
|
group |
BEFREE |
An intact nef gene is essential for rapid development of immunodeficiency in human immunodeficiency virus and simian immunodeficiency virus infections.
|
9691218 |
1998 |
Immunologic Deficiency Syndromes
|
0.100 |
Biomarker
|
group |
BEFREE |
When inoculated into macaque monkeys, SHIV(MD14) carrying simian immunodeficiency virus-derived nef established significantly higher virus loads than did SHIV(MD1), which contains the HIV-1 nef gene.
|
9237701 |
1997 |
Immunologic Deficiency Syndromes
|
0.100 |
GeneticVariation
|
group |
BEFREE |
A chimeric human and simian immunodeficiency virus carrying the tat, rev, vpu, env, and nef genes of human immunodeficiency virus type 1 was generated.
|
7811533 |
1994 |
Immunologic Deficiency Syndromes
|
0.100 |
Biomarker
|
group |
BEFREE |
The nef genes of the human immunodeficiency viruses type 1 and 2 (HIV-1 and HIV-2) and the related simian immunodeficiency viruses (SIVs) encode a protein (Nef) whose role in virus replication and cytopathicity remains uncertain.
|
8043040 |
1993 |
Immunologic Deficiency Syndromes
|
0.100 |
Biomarker
|
group |
BEFREE |
In vivo experiments have indicated that an intact nef gene is required for disease progression in macaques infected with simian immunodeficiency virus, suggesting a role for Nef in the pathogenesis of AIDS.
|
8331733 |
1993 |
Immunologic Deficiency Syndromes
|
0.100 |
Biomarker
|
group |
BEFREE |
Mutational analysis of the simian immunodeficiency virus SIVmac nef gene.
|
1716690 |
1991 |