|
Gastrointestinal Stromal Tumors
|
0.090 |
Biomarker
|
group |
BEFREE |
The IHC characteristic of GIST in descending order showed positivity for vimentin (88.9%), CD117 (83.3%), CD34 (77.8%), Ki67 (63.9%), SMA (38.9%), desmin (27.8%), and S100 (19.4%).
|
30723856 |
2019 |
|
Gastrointestinal Stromal Tumors
|
0.090 |
AlteredExpression
|
group |
BEFREE |
Immnunohistochemistry (IHC) was used to detect CD117, DOG-1, PKC-θ, CD34, Ki-67, α-smooth muscle actin (SMA), S100, and Desmin expression in 147 GISTs and 51 non-GISTs. c-Kit gene (exons 9, 11, 13, and 17) and platelet-derived growth factor receptor-alpha (PDGFRA) gene (exons 12 and 18) mutations were also detected.
|
23862765 |
2013 |
|
Gastrointestinal Stromal Tumors
|
0.090 |
AlteredExpression
|
group |
BEFREE |
Compared with the overall mutation rate of KIT (70%), all GIST with CD117+ and S100+ had > 80% probability of harboring mutated KIT, and the subset with additional CD34+ and SMA- had a mutation rate of 88%.
|
20123583 |
2010 |
|
Gastrointestinal Stromal Tumors
|
0.090 |
Biomarker
|
group |
BEFREE |
Thirty-three GISTs (92%) showed immunoreactivity for KIT, and 23 tumors (64%) showed diffuse or mosaic-like immunoreactivity for S-100 protein.
|
15897742 |
2005 |
|
Gastrointestinal Stromal Tumors
|
0.090 |
Biomarker
|
group |
BEFREE |
Immunohistochemical analysis of KIT, CD34, vimentin, alpha-smooth muscle actin (SMA), s-100, p53, ki-67, bcl-2 and bax expression was performed on 20 surgically resected GIST.
|
12375034 |
2003 |
|
Gastrointestinal Stromal Tumors
|
0.090 |
Biomarker
|
group |
BEFREE |
The percentage of CD34 positivity (38.8%) was low, in contrast with the high percentage of reactivity for SMA (77.8%) and S-100 (44.4%) in small intestine GISTs.
|
12152168 |
2002 |
|
Gastrointestinal Stromal Tumors
|
0.090 |
Biomarker
|
group |
BEFREE |
Approximately 70% of GISTs are positive for CD34, 20-30% are positive for smooth muscle actin (SMA), 10% are positive for S100 protein and <5% are positive for desmin.
|
11213830 |
2001 |
|
Gastrointestinal Stromal Tumors
|
0.090 |
Biomarker
|
group |
BEFREE |
Because the tumor expressed CD34 and c-kit gene product, but did not express smooth muscle actin or S-100 protein, it was diagnosed as an uncommitted type of GIST.
|
11063223 |
2000 |
|
Gastrointestinal Stromal Tumors
|
0.090 |
AlteredExpression
|
group |
BEFREE |
Otherwise, the expression of SMemb in GIST was not correlated with the patient's age or sex, tumor size, histological grade of GIST, or expression of mesenchymal cell markers, such as alpha-smooth muscle actin (alpha-SMA) or S100 protein.
|
9916914 |
1999 |