SERPINB3, serpin family B member 3, 6317

N. diseases: 101; N. variants: 1
Disease: Dermatitis, Atopic ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		0.040 Biomarker disease BEFREE SERPINB3&4 promote inflammation and impaired skin barrier function in the early stage of atopic dermatitis. 31184315 2019
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		0.040 Biomarker disease BEFREE Moreover, it has been shown that SCCA1/2 are involved in the pathogenesis of several inflammatory diseases: asthma, psoriasis, and atopic dermatitis (AD). 29642409 2018
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		0.040 Biomarker disease BEFREE In conclusion, Serpinb3a deficiency attenuates barrier dysfunction and the early inflammatory response following cutaneous allergen exposure, supporting a role for Serpinb3a (mice) and SERPINB3/B4 (humans) early in atopic dermatitis. 25111616 2015
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		0.040 Biomarker disease BEFREE We examined whether SCCA1 and SCCA2 could also serve as biomarkers of AD, reflecting its Th2-type immune responses, and whether the expression level of SCCA was correlated with clinical severity of AD. 16238792 2005