Disease: Hypertensive disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.480 GeneticVariation group BEFREE By confocal and cytometry analysis, we determined the α-ENaC distribution and the heterogeneity of HTN neutrophils population, respectively. 30423324 2019
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.480 AlteredExpression group BEFREE As an underlying mechanism cathepsin B induced αENaC processing leading to augmented channel activity and hypertension was identified. 31368174 2019
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.480 GeneticVariation group BEFREE We aimed to synthesize epigenomic findings in HTN namely (a) angiotensin-converting enzyme 2 (ACE II) gene, (b) Toll-like receptor 2 (TLR2) gene, (c) interferon γ (IFN-γ) gene, and (d) Capping Actin Protein, Gelosin-Like (<i>CAPG</i>) <i>gene</i>, adducin 1(ADD1) gene, (e) Tissue inhibitor of metalloproteinase 3 (<i>TIMP3</i>), (f) mesoderm specific transcript (MEST) loci, (g) sodium channel epithelial 1 alpha subunit 2 (SCNN1B), (h) glucokinase (CKG) gene (i) angiotensin II receptor, type1 (AGTR1), and DNA methylation (mDNA). 31805646 2019
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.480 AlteredExpression group BEFREE Post-translational histone methylation at different histone 3 lysine residues was also observed to control the expression of genes related to AH as lysine-specific demethylase-1(LSD1), HSD11B2, and epithelial sodium channel subunit α (SCNN1A). 25035152 2015
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.480 GeneticVariation group BEFREE This exploratory study reports two plausible loci associated with SBP response to hydrochlorothiazide: TET2, an aldosterone-responsive mediator of αENaC gene transcription; and CSMD1, previously described as associated with hypertension in a case-control study. 25695618 2015
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.480 Biomarker group CTD_human Renal tubular NEDD4-2 deficiency causes NCC-mediated salt-dependent hypertension. 23348737 2013
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.480 GeneticVariation group BEFREE Mutations in the alpha-, beta- and gamma-ENaC subunit genes (SCNN1A, SCNN1B and SCNN1G) are associated with multi-system pseudohypoaldosteronism (PHA), and mutations in the PY motif of carboxy-terminal region of beta and gamma subunits are associated with Liddle syndrome of hereditary hypertension. 20064610 2010
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.480 Biomarker group BEFREE The development of Scnn1 genetically engineered mouse models will provide the opportunity to test the effect of environmental factors, like salt intake, on the development of this kind of salt- sensitive hypertension. 12530930 2003
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.480 GeneticVariation group BEFREE Therefore, possession of the SCNN1A G(2139) allele significantly increased the risk of hypertension. 11752024 2002
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.480 Biomarker group CTD_human Therefore, possession of the SCNN1A G(2139) allele significantly increased the risk of hypertension. 11752024 2002
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.480 Biomarker group HPO