|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Although there are several reports on the association of RANTES promoter polymorphisms (-403G/A and -28C/G) with asthma, the association of these polymorphisms with atopic dermatitis has not yet been confirmed in other populations.
|
17117952 |
2006 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
The RANTES -403G/A polymorphism did not influence asthma/atopy susceptibility, blood eosinophil count, or bronchial hyperresponsiveness.
|
12789231 |
2003 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our data suggest that -28 C/G and -403 G/A polymorphisms within the RANTES promoter region play an important role in asthma predisposition and in the severity of airway obstruction.
|
17678722 |
2007 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis suggests that the CCL5 -28C/G polymorphism is a risk factor for asthma.
|
25898691 |
2015 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Association between RANTES gene polymorphisms and asthma: a meta-analysis.
|
24963658 |
2014 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
The polymorphisms within the RANTES promoter may have a disease-modifying effect in Korean children with asthma.
|
17990036 |
2008 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Carriers of both IL-13 A2044G A/A and RANTES G-28C G/G have a more significant risk for developing asthma than those with only a single polymorphism.
|
24053708 |
2013 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We studied 61 patients with asthma and/or atopy and 129 to 157 newborn controls for the -403 RANTES, -28 RANTES, and -1055 IL-13 SNPs, as well as 47 patients and 60 newborn controls for the -444 LTC4S SNP.
|
16024972 |
2005 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The current cluster analysis identified meaningful adult asthma phenotypes linked to the functional CCL5 and ADRB2 genotypes.
|
23267209 |
2013 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
RANTES G-401A was not associated with physician-diagnosed asthma (P = 0.408).
|
15715189 |
2005 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Asthma is a complex inherited disease.The study was undertaken to identify the association of RANTES promoter polymorphisms with atopy and asthma using family-based association tests (FBATs) and generation-specific case-control analyses.
|
15592421 |
2005 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The polymorphisms within the RANTES promoter may have a disease-modifying effect in Korean children with asthma.
|
17990036 |
2008 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We have recently identified a polymorphism within the RANTES promoter (-403 G-->A) and have examined its role, using a PCR-RFLP assay, in the development of atopy and asthma in 201 Caucasian subjects.
|
11197694 |
2000 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our objective was to investigate the possible influence of the CCL5/RANTES promoter polymorphisms in the different types of bronchial asthma.
|
18186796 |
2008 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
It was previously reported that the gain-of-function -28 guanine allele of the promoter single nucleotide polymorphism (SNP; cytosine to guanine substitution of nucleotide -28 (-28C>G)) in the CC chemokine ligand 5 gene (CCL5) was associated with susceptibility to late-onset asthma in patients who developed asthma at age > or =40 yrs.
|
18385174 |
2008 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The RANTES -403G/A polymorphism did not influence asthma/atopy susceptibility, blood eosinophil count, or bronchial hyperresponsiveness.
|
12789231 |
2003 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Previous studies revealed that polymorphisms of RANTES were implicated in susceptibility to asthma, but a large number of studies reported apparently conflicting results.
|
20430255 |
2010 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The promoter polymorphisms in the RANTES gene did not have a detectable effect on the susceptibility to asthma or allergy or on the blood eosinophil count.
|
11544456 |
2001 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A number of studies have evaluated the functional polymorphism -28C/G in the RANTES promoter region, which had been found to affect the transcription of the RANTES gene, in relation to asthma susceptibility.
|
20186291 |
2010 |
|
Dermatitis, Atopic
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
G-401A polymorphism in RANTES promoter was associated with near-fatal asthma and atopic dermatitis in children.
|
15715189 |
2005 |
|
Dermatitis, Atopic
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
Atopic dermatitis is associated with a functional mutation in the promoter of the C-C chemokine RANTES.
|
10640782 |
2000 |
|
Dermatitis, Atopic
|
0.390 |
GeneticVariation
|
disease |
LHGDN |
These results support a role for RANTES promoter polymorphisms in susceptibility to atopic dermatitis.
|
17117952 |
2006 |
|
Dermatitis, Atopic
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
These results support a role for RANTES promoter polymorphisms in susceptibility to atopic dermatitis.
|
17117952 |
2006 |
|
Dermatitis, Atopic
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
We show that miR-146a expression is increased in keratinocytes and chronic lesional skin of patients with AD. miR-146a inhibited the expression of numerous proinflammatory factors, including IFN-γ-inducible and AD-associated genes CCL5, CCL8, and ubiquitin D (UBD) in human primary keratinocytes stimulated with IFN-γ, TNF-α, or IL-1β.
|
24996260 |
2014 |
|
Arteriosclerosis
|
0.290 |
GeneticVariation
|
disease |
BEFREE |
In DM2 patients with ESRD, ACM due to cardiac events is associated with RANTES gene variants that are known to alter the expression of this chemokine important in atherosclerosis.
|
15899487 |
2005 |