CCL8, C-C motif chemokine ligand 8, 6355

N. diseases: 115; N. variants: 5
Disease: Neoplasms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.050 Biomarker group BEFREE In the validation dataset GSE25055 and RSAD2 expression was correlated with tumor grade, stage, and size, whereas HERC5 was related to tumor stage and tumor grade, and CCL8 was associated with tumor size and tumor grade. 31225658 2020
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.050 Biomarker group BEFREE To evaluate whether and how CCL8 enhances the immune response against tumors in 5-aminolevulinic acid (ALA)-mediated PDT. 30902794 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.050 GeneticVariation group BEFREE Eight markers were statistically significantly higher with tumor EBV positivity: chemokine C-C motif ligand (CCL) 20 (Odds Ratio (OR) = 3.6; <i>p</i>-trend = 0.001), chemokine C-X-C motif ligand 9 (OR = 3.6; <i>p</i>-trend = 0.003), programmed death-ligand 1 (PD-L1; OR = 3.4; <i>p</i>-trend = 0.004), interleukin (IL)-10 (OR = 2.4; <i>p</i>-trend = 0.019), CCL19 (OR = 2.3; <i>p</i>-trend = 0.019), CCL11 (OR = 2.2; <i>p</i>-trend = 0.026), IL-17A (OR = 2.0; <i>p</i>-trend = 0.038) and CCL8 (OR = 1.9; <i>p</i>-trend = 0.049). 30142953 2018
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.050 AlteredExpression group BEFREE Manipulation of CCL8 activity influences the histology of the tumors and promotes major steps of the metastatic process such as invasion to adjacent stroma, intravasation and ultimately extravasation and seeding. 27181207 2016
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.050 Biomarker group BEFREE Increased migration of the examined tumor cell lines was observed when CCL8 was applied as a chemoattractant. 26320180 2015