|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
These data suggest that CCL17 and CCL22 produced by TSLP-primed naïve CD4<sup>+</sup> T cells in asthma might contribute to an increase in Th2 cells via autocrine loops.
|
30431203 |
2019 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Higher relative abundance of these bacteria is furthermore associated with an airway immune profile dominated by reduced TNF-α and IL-1β and increased CCL2 and CCL17, which itself is an independent predictor for asthma.
|
31676759 |
2019 |
|
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Sputum TARC levels were significantly higher in children with asthma than in either children with EB (p=0.004) or the control subjects (p=0.014).
|
28238403 |
2017 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Furthermore, macrophages from asthmatics released significant amounts of CCL17 protein in vitro which was also found increased in BAL fluid after allergen provocation.
|
24612750 |
2014 |
|
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
This study does not support the existence in human asthma of the full M2 phenotype described to date but points to upregulation of CCL17 in both patients with mild and those with moderate asthma, providing a further source for this ligand of CCR4(+) cells that contributes to airways inflammation.
|
22981793 |
2012 |
|
Asthma
|
0.300 |
AlteredExpression
|
disease |
LHGDN |
We examined the effects of Der p and the cytokines IL-4 and TGF-beta on TARC expression in 16HBE cells and primary bronchial asthma epithelium.
|
17023689 |
2007 |
|
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
We used in situ hybridization and immunohistochemistry to examine the expression and cellular provenance of TSLP, Th2-attracting (thymus and activation-regulated chemokine (TARC)/CCL17, macrophage-derived chemokine (MDC)/CCL22, I-309/CCL1) and Th1-attracting (IFN-gamma-inducible protein 10 (IP-10)/CXCL10, IFN-inducible T cell alpha-chemoattractant (I-TAC)/CXCL11) chemokines and expression of their receptors CCR4, CCR8, and CXCR3 in bronchial biopsies from 20 asthmatics and 15 normal controls.
|
15944327 |
2005 |
|
Asthma
|
0.300 |
AlteredExpression
|
disease |
LHGDN |
Our data implicate TSLP, TARC/CCL17, MDC/CCL22, and IP-10/CXCL10 in asthma pathogenesis.
|
15944327 |
2005 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
RGD |
In contrast to the findings in the asthma and lung fibrosis models, the increased expression of MDC and TARC in the cigarette-smoke model was not associated with an increased infiltration of Th2 cells into smoke-treated lungs.
|
15993846 |
2005 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Th2-specific chemokine thymus and activation-regulated chemokine (TARC)/CC chemokine ligand (CCL)17 is highly implicated in the pathogenesis of Th-2-dominated allergic diseases such as bronchial asthma (BA) and atopic dermatitis (AD).
|
12557061 |
2003 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Recent studies report that TARC and MDC may serve as pivotal chemokines for the development of Th2-dominated experimental allergen-induced asthma.
|
12645858 |
2003 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
We investigated the effects of suplatast tosilate on the production of thymus- and activation-regulated chemokine (TARC) by T cells from allergic patients with asthma.
|
12653172 |
2002 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Expression of the CCR4-specific ligands MDC and TARC is strongly upregulated on airway epithelial cells upon allergen challenge, suggesting an involvement of this receptor/ligand axis in the regulation of lymphocyte recruitment into the asthmatic bronchi.
|
11390417 |
2001 |