Dermatitis, Atopic
|
0.400 |
Biomarker
|
disease |
BEFREE |
T<sub>H</sub>2 chemokines (CCL13, CCL17) were consistently elevated in patients with AD across all ages (P < .05), whereas T<sub>H</sub>1 (CXCL10) and T<sub>H</sub>17 (KYNU, CCL20) markers incrementally increased with age in both patients with AD and healthy subjects.
|
31622668 |
2020 |
Dermatitis, Atopic
|
0.400 |
Biomarker
|
disease |
BEFREE |
CXCL8, CCL2 and CCL17 showed an association with objective SCORing Atopic Dermatitis score.
|
29989151 |
2019 |
Dermatitis, Atopic
|
0.400 |
Biomarker
|
disease |
BEFREE |
IL-4 Augments IL-31/IL-31 Receptor Alpha Interaction Leading to Enhanced Ccl 17 and Ccl 22 Production in Dendritic Cells: Implications for Atopic Dermatitis.
|
31434203 |
2019 |
Dermatitis, Atopic
|
0.400 |
Biomarker
|
disease |
BEFREE |
Identified biomarkers of AD severity included T helper 2-skewed markers [interleukin (IL)-13, CCL17, CCL22, IL-5]; markers of innate activation (IL-18, IL-1α, IL1β, CXCL8) and angiogenesis (Flt-1, vascular endothelial growth factor); and others (soluble intercellular adhesion molecule-1, soluble vascular cell adhesion molecule-1, IL-16, IL-17A).
|
30132823 |
2019 |
Dermatitis, Atopic
|
0.400 |
Biomarker
|
disease |
BEFREE |
Among the biomarkers tested, serum SCCA2 also showed the best correlations with clinical AD severity and TARC and showed the best diagnosability for AD in ROC analysis.
|
31378660 |
2019 |
Dermatitis, Atopic
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Consistently, the frequency of TIGIT<sup>+</sup> cells among CD4<sup>+</sup> T cells was negatively correlated with both serum thymus and activation-regulated chemokine levels and immunoglobulin E levels in patients with AD.
|
30402886 |
2019 |
Dermatitis, Atopic
|
0.400 |
Biomarker
|
disease |
BEFREE |
We found that AD S. aureus<sup>+</sup> patients had more severe disease based on all scoring systems except itch (Numerical Rating Scale), and they had higher levels of type 2 biomarkers (eosinophil count, tIgE, CCL17, and periostin).
|
29604251 |
2018 |
Dermatitis, Atopic
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Laboratory data for CIE and AD were similar, but serum levels of thymus and activation-regulated chemokine (TARC), a T-helper (Th) 2 cytokine, in the CIE group were significantly more elevated than in the AD group.
|
29590497 |
2018 |
Dermatitis, Atopic
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
SP treatment significantly reduced the infiltration of mast cells and CD3-positive T cells as well as inflammatory cytokines, such as tumor necrosis factor-α (TNF-α) and thymic stromal lymphopoietin (TSLP), in AD-like skin lesions and decreased the levels of IgE and thymus and activation-regulated chemokine in serum.
|
28833499 |
2018 |
Dermatitis, Atopic
|
0.400 |
Biomarker
|
disease |
BEFREE |
These findings indicate that Glyteer may exhibit therapeutic potential for AD by downregulating the CCL17 and CCL22 production from DCs in a Th2-deviated microenvironment.
|
29649105 |
2018 |
Dermatitis, Atopic
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this study, we report that Lactobacillus strains have a significant suppressive effect on tumour necrosis factor (TNF)-α-induced expression and production of thymus and activation-regulated chemokine (TARC), a T helper 2 cell chemokine responsible for atopic dermatitis, in human keratinocytes.
|
29798706 |
2018 |
Dermatitis, Atopic
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Increases in serum cytokines and chemokines (IL-13, IL-22, CCL17) were found in AD versus healthy individuals and were reduced with treatment.
|
27825969 |
2017 |
Dermatitis, Atopic
|
0.400 |
Biomarker
|
disease |
BEFREE |
Levels of inflammatory cytokines and chemokines, such as thymus- and activation-regulated chemokine (TARC), macrophage-derived chemokine, and thymic stromal lymphopoietin (TSLP), were examined in human keratinocytes supplemented with or without CTP under AD-like inflammation.
|
29017796 |
2017 |
Dermatitis, Atopic
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We identified unique signatures for AD (Immunoglobulin E (IgE), thymus- and activation-regulated chemokine (TARC) and macrophage-derived chemokine (MDC)), CD (10 proteins), and PS (kynureninase (KYNU)).
|
28703865 |
2017 |
Dermatitis, Atopic
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
They produced both AD (CCL17/18/22) and maturation-related (CCL3/4/5) chemokines at higher level than controls.
|
27701668 |
2017 |
Dermatitis, Atopic
|
0.400 |
Biomarker
|
disease |
BEFREE |
Th2-related chemokines such as thymus and activation-regulated chemokine (TARC/CCL17) and macrophage-derived chemokine (MDC/CCL22), and pro-inflammatory cytokines including interleukin (IL)-1β and IL-6 are considered to play a crucial role in AD.
|
28958612 |
2017 |
Dermatitis, Atopic
|
0.400 |
Biomarker
|
disease |
BEFREE |
Oral administration of L. chungangensis CAU 28(T) suppressed the production of IL-4, IL-5, IL-12, IFN-γ, tumor necrosis factor-α, and thymus- and activation-regulated chemokine (TARC) in skin lesions, indicating that it strongly drives the local immune system with efficacy comparable to that of tacrolimus, a topical immunomodulatory drug used for the treatment of atopic dermatitis.
|
27289147 |
2016 |
Dermatitis, Atopic
|
0.400 |
Biomarker
|
disease |
BEFREE |
We aimed to investigate the effects of DHE-Glc, a synthetic molecule derived from ergosterol, on AD-like skin lesions induced by 2,4-dinitrochlorobenzene (DNCB) in mice and to elucidate the effects of DHE-Glc on TNF-α/IFN-γ-induced production of CCL17 and CCL22 in human keratinocytes (HaCaTs) and DNCB induced skin inflammation mice model.
|
26100037 |
2015 |
Dermatitis, Atopic
|
0.400 |
Biomarker
|
disease |
BEFREE |
The Th9 cell percentage, PU.1 and IL-9 expression levels of AD patients were all increased significantly compared with the other two control groups (P < 0·01), and correlated positively with SCORing Atopic Dermatitis index, serum immunoglobulin (Ig)E and thymus- and activation-regulated chemokine (TARC) levels (P < 0·05).
|
24032555 |
2014 |
Dermatitis, Atopic
|
0.400 |
Biomarker
|
disease |
BEFREE |
Chemokines are important mediators of cell migration, and thymus and activation-regulated chemokine (TARC/CCL17) and macrophage-derived chemokine (MDC/CCL22) are well-known typical inflammatory chemokines involved in atopic dermatitis (AD).
|
24704449 |
2014 |
Dermatitis, Atopic
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that CG inhibited the development of the AD-like skin symptoms by modulating Th1 and Th2 responses in the skin lesions in mice and TARC expression by suppressing TNF-α/IFN-γ-induced NF-κB activation in keratinocytes, and so may be a useful tool in the therapy of AD-like skin symptoms.
|
23454147 |
2013 |
Dermatitis, Atopic
|
0.400 |
Biomarker
|
disease |
BEFREE |
We examined plasma LIGHT levels, total serum IgE, serum value of CCL17 and peripheral blood eosinophil counts in patients with AD and healthy subjects.
|
22519595 |
2012 |
Dermatitis, Atopic
|
0.400 |
Biomarker
|
disease |
BEFREE |
Recent clinical studies have shown important roles of the Th2 chemokines, CCL22 and CCL17 in the pathogenesis of AD.
|
22125604 |
2011 |
Dermatitis, Atopic
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Among several cytokines and chemokines produced in the skin, CCL17, which is highly expressed in AD, was found to be a strong inducer of AQP3 expression and enhanced keratinocyte proliferation.
|
21191421 |
2011 |
Dermatitis, Atopic
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
A minor CCL17 mRNA increase was measured in lesional psoriatic skin.No alterations were found in AD.
|
21707761 |
2011 |