CX3CL1, C-X3-C motif chemokine ligand 1, 6376

N. diseases: 243; N. variants: 6
Disease: Neuralgia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.040 Biomarker phenotype BEFREE Because chemokine fractalkine (CX3CL1) has been suggested as an important signal during neuropathic pain development, this study aimed to investigate whether CX3CL1 expression may be modulated by EGCG treatment reducing hyperalgesia in chronic constriction injured mice. 27896922 2017
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.040 Biomarker phenotype BEFREE CX3CL1 (fractalkine), the sole member of chemokine CX3C family, is implicated in inflammatory and neuropathic pain via activating its receptor CX3CR1 on neural cells in spinal cord. 28776289 2017
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.040 Biomarker phenotype BEFREE Our results suggest that microglia are involved in pruritus induced by DNFB via FKN/CX3CR1/p38MAPK pathways similar to those participating in the development of neuropathic pain. 25661672 2015
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.040 Biomarker phenotype BEFREE Molecular signaling through fractalkine (CX3CL1), a nociceptive chemokine, via its receptor (CX3CR1) is thought to be associated with MS-induced NPP. 24175290 2013