Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Our findings thus demonstrate neuronal SR association with DISC1 and its agglomerates, which can be modulated by d-Serine, thereby validating a novel neuronal SR-DISC1 complex responsive to NMDAR activation and providing a molecular mechanism by which pathways implicated in schizophrenia converge.
|
30391323 |
2019 |
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Genome-Wide Association Study Detected Novel Susceptibility Genes for Schizophrenia and Shared Trans-Populations/Diseases Genetic Effect.
|
30285260 |
2019 |
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Serine racemase knockout mice demonstrate abnormalities in socio-communicative behaviors consistent with an impairment in sociality, a negative symptom of schizophrenia.
|
31515952 |
2019 |
Schizophrenia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
The enzymes involved in its formation and catabolism are serine racemase (SR) and D-amino acid oxidase (DAAO), respectively, and manipulations of the activity of those enzymes have been useful in developing animal models of schizophrenia and in providing clues to the development of potential new antipsychotic strategies.
|
30787885 |
2019 |
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We used transgenic mice with a null mutation of the gene encoding serine racemase (SR), the enzyme that synthesizes the NMDAR co-agonist d-serine and an established risk gene for SZ, to recreate the pathology of SZ.
|
29168271 |
2019 |
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Association of Schizophrenia Risk With Disordered Niacin Metabolism in an Indian Genome-wide Association Study.
|
31268507 |
2019 |
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Nowadays, SR deregulation is associated with a wide range of neurological and psychiatric diseases including schizophrenia, amyotrophic lateral sclerosis, and depression.
|
30555832 |
2018 |
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia.
|
28540026 |
2017 |
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Inactivation of one of these risk genes that encodes serine racemase, which synthesizes D-serine, an NMDAR co-agonist, reproduces the synaptic pathology of schizophrenia.
|
26954593 |
2016 |
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study of schizophrenia in Ashkenazi Jews.
|
26198764 |
2015 |
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Biological insights from 108 schizophrenia-associated genetic loci.
|
25056061 |
2014 |
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
|
23974872 |
2013 |
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
|
23974872 |
2013 |
Schizophrenia
|
0.700 |
Biomarker
|
disease |
PSYGENET |
Pathogenic disruption of DISC1-serine racemase binding elicits schizophrenia-like behavior via D-serine depletion.
|
22801410 |
2013 |
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Multiple risk pathways for schizophrenia converge in serine racemase knockout mice, a mouse model of NMDA receptor hypofunction.
|
23729812 |
2013 |
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Pathogenic disruption of DISC1-serine racemase binding elicits schizophrenia-like behavior via D-serine depletion.
|
22801410 |
2013 |
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
This study demonstrates that aberrant Srr function and diminished d-serine may contribute to schizophrenia pathogenesis.
|
19483194 |
2009 |
Schizophrenia
|
0.700 |
Biomarker
|
disease |
PSYGENET |
This study demonstrates that aberrant Srr function and diminished d-serine may contribute to schizophrenia pathogenesis.
|
19483194 |
2009 |
Schizophrenia
|
0.700 |
Biomarker
|
disease |
MGD |
This study demonstrates that aberrant Srr function and diminished d-serine may contribute to schizophrenia pathogenesis.
|
19483194 |
2009 |
Schizophrenia
|
0.700 |
Biomarker
|
disease |
MGD |
Targeted disruption of serine racemase affects glutamatergic neurotransmission and behavior.
|
19065142 |
2009 |
Schizophrenia
|
0.700 |
Biomarker
|
disease |
PSYGENET |
The IVS1a+465C allele of the SRR gene, which reduces expression of the gene, is a risk factor for schizophrenia, especially the paranoid subtype.
|
17067558 |
2007 |
Schizophrenia
|
0.700 |
AlteredExpression
|
disease |
LHGDN |
These findings establish the major cell types wherein serine racemase and D-amino acid oxidase are expressed in human brain and provide some support for aberrant D-serine metabolism in schizophrenia.
|
17880399 |
2007 |
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The IVS1a+465C allele of the SRR gene, which reduces expression of the gene, is a risk factor for schizophrenia, especially the paranoid subtype.
|
17067558 |
2007 |
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Serine racemase binds to PICK1: potential relevance to schizophrenia.
|
16314870 |
2006 |
Schizophrenia
|
0.700 |
AlteredExpression
|
disease |
LHGDN |
We studied the expression of serine racemase, an astrocytic enzyme which synthesizes the N-methyl-D-aspartate receptor coagonist D-serine, using Western blot analysis in postmortem hippocampus and cortex in schizophrenia and a comparison group.
|
16837850 |
2006 |