|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we hypothesized that microRNA-23a (miR-23a) affects the cell proliferation, migration, and invasion of melanoma with a mechanism related to SDCBP and the MAPK/ERK signaling pathway.
|
30589231 |
2019 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
This review focuses on a unique gene, melanoma differentiation associated gene-9 (also known as Syntenin-1; Syndecan Binding Protein (sdcbp); mda-9/syntenin), initially cloned and characterized from metastatic human melanoma and shown to be a pro-metastatic gene.
|
31349898 |
2019 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We identified melanoma differentiation-associated gene-9 (MDA-9)/syntenin, an adaptor protein implicated in tumor metastasis, as a novel direct target of miR-139-3p and showed that syntenin mRNA and miR-139-3p levels were inversely correlated in clinical specimens (r = -0.6817, P = 0.0002).
|
30502089 |
2019 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Melanoma differentiation-associated gene 9 (MDA-9)/Syntenin is a multidomain PDZ protein and identified as a key oncogene in melanoma initially.
|
30766662 |
2019 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Based on bioinformatics data, we predicted an association of melanoma differentiation-associated gene-9 [syntenin, or syndecan binding protein (SDCBP)] in prostate cancer progression.
|
29572229 |
2018 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Syntenin1/SDCBP (syndecan binding protein), also known as melanoma differentiation associated gene-9 (MDA-9), is a PDZ domain-containing molecule, which was initially identified as a key oncogene in melanoma.
|
29845474 |
2018 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Subtraction hybridization identified melanoma differentiation-associated gene 9 [MDA-9/Syntenin; syndecan-binding protein (SDCBP)] as a differentially regulated gene associated with aggressive cancer phenotypes in melanoma.
|
28011764 |
2017 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Melanoma differentiation-associated gene-9 (MDA-9)/Syntenin is a novel therapeutic target because it plays critical roles in cancer progression and exosome biogenesis.
|
26561205 |
2016 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Among them, seven proteins (α-enolase, cofilin-1, LDH, m-β-actin, Nm23, GRP78, and MDA-9) showed increased and one (annexin A2) showed decreased expression in metastatic lymph node tissues than in primary melanomas.
|
25480418 |
2015 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Induction of MDA-9/syntenin in melanoma was found to occur in a thrombin-independent signaling pathway and involves the PAR-1/c-Src/Rho GTPases Rac1 and Cdc42/c-Jun N-terminal kinase axis resulting in the activation of paxillin, NF-κB, and matrix metalloproteinase-2 (MMP-2).
|
25505176 |
2015 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
MDA-9/syntenin and IGFBP-2 promote angiogenesis in human melanoma.
|
23233738 |
2013 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Syndecan binding protein (SDCBP), an adapter protein containing PDZ domains, contributes to the tumorigenicity and metastasis of many malignant tumors, such as malignant melanoma.
|
23533663 |
2013 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, these findings establish RKIP as an inhibitor of MDA-9-dependent melanoma metastasis, with potential implications for targeting this process therapeutically.
|
23066033 |
2012 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
MDA-9/syntenin: a positive gatekeeper of melanoma metastasis.
|
22201728 |
2012 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
MDA-9/syntenin also promotes melanoma metastasis by activating c-Src, but how c-Src regulates NF-kappaB activation is unclear.
|
20228839 |
2010 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Melanoma differentiation associated gene-9 (mda-9), also known as syntenin, is a PDZ domain-containing adapter protein that is involved in organization of protein complexes in the plasma membranes, regulation of B-cell development, intracellular trafficking and cell-surface targeting, synaptic transmission, and axonal outgrowth.
|
18451132 |
2008 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results highlight the importance of mda-9/syntenin as a key component of melanoma metastasis providing a rational molecular target for potentially intervening in the metastatic process.
|
17308124 |
2007 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression of mda-9/syntenin correlates with advanced stages of melanoma progression.
|
16322237 |
2005 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Melanoma metastasis is associated with enhanced expression of the syntenin gene.
|
15254681 |
2004 |