Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.020 AlteredExpression disease BEFREE To investigate the role of this gene for non-small cell lung cancer, we compared the relationship between p53AIP1 gene expression and clinicopathological status of lung cancer. 17851056 2008
CUI: C3714514
Disease: Infection
Infection 		0.020 AlteredExpression group LHGDN Difference of p53AIP1 mRNA expression in gastric mucosa between patients with gastric cancer and chronic gastritis infected with Helicobacter pylori. 18277906 2008
CUI: C3714514
Disease: Infection
Infection 		0.020 AlteredExpression group LHGDN Insights in gastric carcinogenesis from Helicobacter pylori infection. 18277909 2008
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.010 AlteredExpression disease BEFREE Transgenic technology was used to enhance the expression of TP53AIP1 in breast cancer cell lines, MDA-MB-415 and MDA-MB-468, and to observe the effects of gene overexpression on the proliferation, cell cycle, and apoptosis of breast cancer cells. 31281721 2019
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas 		0.010 Biomarker group BEFREE The mechanism of TP53AIP1 inhibition of proliferation and growth of breast cancer cells includes cell cycle arrest, apoptosis promotion (<i>p</i> < 0.01), promotion of the expression of cleaved-caspase-3 (<i>p</i> < 0.01), cleaved-caspase-9 (<i>p</i> < 0.01), B cell lymphoma/leukemia-2 (Bcl-2)-associated X protein, and p53 (<i>p</i> < 0.01), and the inhibition of Bcl-2, Ki67, and PI3K/Akt pathways (<i>p</i> < 0.01). 31281721 2019
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.010 AlteredExpression disease BEFREE Transgenic technology was used to enhance the expression of TP53AIP1 in breast cancer cell lines, MDA-MB-415 and MDA-MB-468, and to observe the effects of gene overexpression on the proliferation, cell cycle, and apoptosis of breast cancer cells. 31281721 2019
CUI: C0025202
Disease: melanoma
melanoma 		0.010 AlteredExpression disease BEFREE Additionally, we showed that TP53AIP1 mRNA was strongly down-regulated throughout different phases of melanoma progression. 29359367 2018
CUI: C0151779
Disease: Cutaneous Melanoma
Cutaneous Melanoma 		0.010 GeneticVariation disease BEFREE In all patients, TP53AIP1 truncating variants were strongly associated with CMM risk (two-sided Fisher exact test = 0.004, OR = 3.3[1.3-8.5]). 29359367 2018
CUI: C0002020
Disease: Alexithymia
Alexithymia 		0.010 Biomarker phenotype BEFREE From our analysis, variants in the genes ABCB4, TP53AIP1, ARHGAP32 and TMEM88B were identified linked to the alexithymia phenotype. 25882097 2015
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.010 AlteredExpression disease BEFREE We further demonstrate that HBx-deregulated increased p53AIP1 expression is relevant in HCC livers and define a functional role for p53AIP1 in mediating HBx-induced apoptosis in vitro. 23149944 2013
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.010 Biomarker group LHGDN p53AIP1 expression can be a prognostic marker in non-small cell lung cancer. 17851056 2008
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.010 AlteredExpression disease BEFREE In the antrum, p53AIP1 mRNA expression was significantly lower in patients with gastric cancer than in those with chronic gastritis (P<0.05). 18277906 2008
CUI: C0085695
Disease: Chronic gastritis
Chronic gastritis 		0.010 AlteredExpression disease BEFREE Difference of p53AIP1 mRNA expression in gastric mucosa between patients with gastric cancer and chronic gastritis infected with Helicobacter pylori. 18277906 2008
CUI: C0334037
Disease: Intestinal metaplasia
Intestinal metaplasia 		0.010 AlteredExpression phenotype BEFREE In patients with chronic gastritis, antral mucosa with high p53AIP1 expression tended to have severe intestinal metaplasia.No mutation was found at p53 codon-46. 18277906 2008
CUI: C0374997
Disease: Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site
Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site 		0.010 AlteredExpression disease BEFREE Difference of p53AIP1 mRNA expression in gastric mucosa between patients with gastric cancer and chronic gastritis infected with Helicobacter pylori. 18277906 2008
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.010 Biomarker phenotype BEFREE H. pylori infection induces gastric mucosal inflammation and DNA damage of epithelial cells, which associate with gastric carcinogenesis. p53AIP1 is expressed after DNA damage and induces apoptosis in human cell lines. 18277906 2008
CUI: C0686619
Disease: Secondary malignant neoplasm of lymph node
Secondary malignant neoplasm of lymph node 		0.010 AlteredExpression disease BEFREE p53AIP1 gene expression levels in the lymph node metastasis-positive group were significantly lower than in the negative group (positive 35.1+/-83.9; negative 64.2+/-113.4; P=0.0486). 17851056 2008
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma 		0.010 AlteredExpression disease BEFREE In the antrum, p53AIP1 mRNA expression was significantly lower in patients with gastric cancer than in those with chronic gastritis (P<0.05). 18277906 2008
CUI: C0850666
Disease: Infection caused by Helicobacter pylori
Infection caused by Helicobacter pylori 		0.010 AlteredExpression disease BEFREE To examine the significance of alteration of p53-regulated apoptosis-induced protein 1 (p53AIP1) expression in gastric carcinogenesis in patients with Helicobacter pylori infection. 18277906 2008
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.010 AlteredExpression group LHGDN Mutant p53 expression enhances drug resistance in a hepatocellular carcinoma cell line. 15004724 2004